Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review.
Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review.
复制标题
肝脏恶性孤立性纤维瘤的颅底转移。
DOI：
10.1186/1746-1596-6-127
复制
发表时间：
2011-12-22
影响因子：
2.6
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Peng L;Liu Y;Ai Y;Liu Z;He Y;Liu Q
肝脏孤立性纤维瘤（SFTs）很少被描述，文献中仅报道了38例，其中大多数表现为良性临床特征，其中只有3例表现为恶性变异。在这项研究中，我们提出了一个24岁的女性有一个月的历史，迅速扩大腹部肿块和CT显示外生性异质性肝脏肿块与坚实的顶骨肿块。患者在术前接受了经导管动脉化疗栓塞术（TACE），并在全身麻醉下进行了扩大的右半肝切除术和颅骨切除术，切缘阴性。肿块的组织学特征为椭圆形梭形细胞杂乱排列，呈典型的短故事状或所谓的无模式的孤立性纤维瘤。免疫组化显示肿瘤细胞对CD 34和bcl-2呈阳性反应。术后2个月肿瘤在残余肝脏复发，术后3个月在胸腰椎发现转移性成骨细胞病变，术后7个月腰椎转移使患者瘫痪。患者接受了经皮无水乙醇注射治疗（PEI）和化疗，但患者在初次手术后16个月因肿瘤不受控制而死亡。据我们所知，这是第一例恶性孤立性肝纤维瘤骨转移。
Solitary fibrous tumors (SFTs) of the liver are rarely described; only 38 cases have been reported in literature, most of which have shown benign clinical characteristics, and only 3 of these cases exhibited malignant variants. In this study, we present a 24-year-old woman with a 1-month history of a rapidly enlarging abdominal mass and a CT showing an exophytic heterogeneous liver mass with a firm parietal bone mass. The patient underwent a transcatheter arterial chemoembolization (TACE) before operation, and an extended right hepatectomy and craniectomy with a negative margin was performed under general anesthesia. The masses showed histological features of oval spindle cells haphazardly arranged in the classic short-storiform or so-called patternless pattern of solitary fibrous tumors. The tumor cells showed positive immunohistochemical reactions to CD34 and bcl-2. The tumor recurred in the residual liver 2 months after operation, metastatic osteoblastic lesions in the thoracic and lumbar vertebrae were identified 3 months after the operation, and lumbar vertebrae metastasis 7 months after operation paralyzed the patient. The patient underwent percutaneous ethanol injection therapy (PEI) and chemotherapy, but the patient died because of the uncontrolled tumor 16 months after the initial operation. To our knowledge, this is the first case of malignant solitary fibrous liver tumors with skeletal metastasis.
登录
查看更多内容
影响因子：
5
作者：
Fuksbrumer, MS;Klimstra, D;Panicek, DM
通讯作者：
Panicek, DM
影响因子：
5.6
作者：
WITKIN, GB;ROSAI, J
通讯作者：
ROSAI, J
影响因子：
1.3
作者：
Clayton, AC;Salomao, DR;Nascimento, AG
通讯作者：
Nascimento, AG
DOI：
10.1259/bjr/98393711
发表时间：
2008-12-01
期刊：
The British journal of radiology
影响因子：
--
作者：
Kandpal, H;Sharma, R;Kumar, A
通讯作者：
Kumar, A
影响因子：
3.4
作者：
Bishop, Justin A.;Rekhtman, Natasha;Ali, Syed Z.
通讯作者：
Ali, Syed Z.