From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity.
From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity.
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DOI：
10.1007/978-3-319-47754-1_4
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发表时间：
2017
影响因子：
--
通讯作者：
DeLouise L
中科院分区：
文献类型：
--
作者：
Graham UM;Jacobs G;Yokel RA;Davis BH;Dozier AK;Birch ME;Tseng MT;Oberdörster G;Elder A;DeLouise L
由于职业和环境暴露于人造纳米颗粒而对人类健康产生的不利影响令人担忧，并对纳米材料的持续工业使用和商业产品整合构成潜在威胁。本章讨论了剂量和反应之间的相互关系，并将阐明如何在细胞和亚细胞水平的纳米粒子的动态化学和物理转化和分解可以导致在体内形成新的反应产物。剂量-反应关系由于生物系统的动力学引起的纳米颗粒中的连续物理化学转化而变得复杂，其中剂量、生物处理和反应以非线性方式相关。纳米级的变化监测使用高分辨率成像结合原位元素分析和重点放在表征的精度的重要性。其结果是对起始粒子，生物环境中的粒子转化以及生理反应的深入了解。
Adverse human health impacts due to occupational and environmental exposures to manufactured nanoparticles are of concern and pose a potential threat to the continued industrial use and integration of nanomaterials into commercial products. This chapter addresses the inter-relationship between dose and response and will elucidate on how the dynamic chemical and physical transformation and breakdown of the nanoparticles at the cellular and subcellular levels can lead to the in vivo formation of new reaction products. The dose-response relationship is complicated by the continuous physicochemical transformations in the nanoparticles induced by the dynamics of the biological system, where dose, bio-processing, and response are related in a non-linear manner. Nanoscale alterations are monitored using high-resolution imaging combined with in situ elemental analysis and emphasis is placed on the importance of the precision of characterization. The result is an in-depth understanding of the starting particles, the particle transformation in a biological environment, and the physiological response.
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影响因子：
10.4
作者：
Bonner JC;Silva RM;Taylor AJ;Brown JM;Hilderbrand SC;Castranova V;Porter D;Elder A;Oberdörster G;Harkema JR;Bramble LA;Kavanagh TJ;Botta D;Nel A;Pinkerton KE
通讯作者：
Pinkerton KE
影响因子：
3.9
作者：
Gebauer, Julia S.;Malissek, Marcelina;Treuel, Lennart
通讯作者：
Treuel, Lennart
影响因子：
2.2
作者：
Anderson, SC;Birkeland, CR;Cockayne, DJH
通讯作者：
Cockayne, DJH
影响因子：
2.8
作者：
Graham, Uschi M.;Khatri, Rajesh A.;Davis, Burtron H.
通讯作者：
Davis, Burtron H.
影响因子：
2.1
作者：
Elder, ACP;Gelein, R;Oberdörster, G
通讯作者：
Oberdörster, G