Model-based feature construction for multivariate decoding.
Model-based feature construction for multivariate decoding.
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DOI:
10.1016/j.neuroimage.2010.04.036
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发表时间:
2011-05-15
期刊:
影响因子:
5.7
通讯作者:
Stephan KE
中科院分区:
文献类型:
--
作者:
Brodersen KH;Haiss F;Ong CS;Jung F;Tittgemeyer M;Buhmann JM;Weber B;Stephan KE
Conventional decoding methods in neuroscience aim to predict discrete brain states from multivariate correlates of neural activity. This approach faces two important challenges. First, a small number of examples are typically represented by a much larger number of features, making it hard to select the few informative features that allow for accurate predictions. Second, accuracy estimates and information maps often remain descriptive and can be hard to interpret. In this paper, we propose a model-based decoding approach that addresses both challenges from a new angle. Our method involves (i) inverting a dynamic causal model of neurophysiological data in a trial-by-trial fashion; (ii) training and testing a discriminative classifier on a strongly reduced feature space derived from trial-wise estimates of the model parameters; and (iii) reconstructing the separating hyperplane. Since the approach is model-based, it provides a principled dimensionality reduction of the feature space; in addition, if the model is neurobiologically plausible, decoding results may offer a mechanistically meaningful interpretation. The proposed method can be used in conjunction with a variety of modelling approaches and brain data, and supports decoding of either trial or subject labels. Moreover, it can supplement evidence-based approaches for model-based decoding and enable structural model selection in cases where Bayesian model selection cannot be applied. Here, we illustrate its application using dynamic causal modelling (DCM) of electrophysiological recordings in rodents. We demonstrate that the approach achieves significant above-chance performance and, at the same time, allows for a neurobiological interpretation of the results.
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影响因子:
7.8
作者:
Brodersen, Kay H.;Penny, Will D.;Stephan, Klaas E.
通讯作者:
Stephan, Klaas E.
影响因子:
3.7
作者:
Felleman, Daniel J.;Van Essen, David C.
通讯作者:
Van Essen, David C.
影响因子:
5.7
作者:
Friston, Karl J.;Mattout, Jeremie;Penny, Will
通讯作者:
Penny, Will
DOI:
10.1016/j.clinph.2008.11.029
发表时间:
2009-03
期刊:
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子:
--
作者:
Garrido MI;Kilner JM;Stephan KE;Friston KJ
通讯作者:
Friston KJ
影响因子:
5.7
作者:
Bode, Stefan;Haynes, John-Dylan
通讯作者:
Haynes, John-Dylan