Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome.
Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome.
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DOI：
10.1093/pm/pnab338
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发表时间：
2022-05-30
期刊：
影响因子：
3.1
通讯作者：
Dorris, Emma R.
中科院分区：
文献类型：
--
作者：
Goebel, Andreas;Andersson, David;Barker, Chris;Basu, Neil;Bullock, Craig;Bevan, Stuart;Bashford-Rogers, Rachael J. M.;Choy, Ernest;Clauw, David;Dulake, Debra;Dulake, Richard;Flor, Herta;Glanvill, Marcia;Helyes, Zsuzsanna;Irani, Sarosh;Kosek, Eva;Laird, Jennifer;MacFarlane, Gary;McCullough, Hayley;Marshall, Andrew;Moots, Robert;Perrot, Serge;Shenker, Nick;Sher, Emanuele;Sommer, Claudia;Svensson, Camilla, I;Williams, Amanda;Wood, Geoff;Dorris, Emma R.
纤维肌痛综合征（FMS）是风湿病中最常见的慢性广泛性疼痛。直到最近，还没有明确的纤维肌痛的病理生理机制，导致管理的挑战。最近的研究表明，血清免疫球蛋白G（IgG）可能在FMS中发挥作用。我们进行了一项研究优先排序工作，以确定最相关的研究方法，可能导致临床可实施的输出。研究优先事项的确定分五个阶段进行：情况分析;设计;专家组协商;临时建议;协商和修订。采用了对话模式，并邀请了一个国际多利益攸关方专家组。临床、患者、行业、资助者和科学专家自始至终都有代表。通过自愿封闭的电子调查确定建议共识。采用了卫生研究优先事项确定报告指南，以支持实施和最大限度地发挥影响。在专家组协商（n = 29名参与者）中，确定了39项临时建议。共识调查的回应率为81.5%。6项建议被确定为高度优先，15项建议被确定为中度优先。建议的范围从纤维肌痛的特点，应考虑在未来的自身抗体研究，具体的免疫学调查，FMS试验设计的建议，和治疗干预措施，应在试验中进行评估。通过应用战略优先级设置的原则，我们将研究导向可实施的领域，从而加速FMS患者人群的获益。这些建议是为患者，国际专业人士和赠款机构关注的原因和管理的纤维肌痛综合征患者的研究。
Fibromyalgia syndrome (FMS) is the most common chronic widespread pain condition in rheumatology. Until recently, no clear pathophysiological mechanism for fibromyalgia had been established, resulting in management challenges. Recent research has indicated that serum immunoglobulin Gs (IgGs) may play a role in FMS. We undertook a research prioritisation exercise to identify the most pertinent research approaches that may lead to clinically implementable outputs. Research priority setting was conducted in five phases: situation analysis; design; expert group consultation; interim recommendations; consultation and revision. A dialogue model was used, and an international multi-stakeholder expert group was invited. Clinical, patient, industry, funder, and scientific expertise was represented throughout. Recommendation-consensus was determined via a voluntary closed eSurvey. Reporting guideline for priority setting of health research were employed to support implementation and maximise impact. Arising from the expert group consultation (n = 29 participants), 39 interim recommendations were defined. A response rate of 81.5% was achieved in the consensus survey. Six recommendations were identified as high priority- and 15 as medium level priority. The recommendations range from aspects of fibromyalgia features that should be considered in future autoantibody research, to specific immunological investigations, suggestions for trial design in FMS, and therapeutic interventions that should be assessed in trials. By applying the principles of strategic priority setting we directed research towards that which is implementable, thereby expediating the benefit to the FMS patient population. These recommendations are intended for patients, international professionals and grant-giving bodies concerned with research into causes and management of patients with fibromyalgia syndrome.
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影响因子：
16.2
作者：
Dawes JM;Weir GA;Middleton SJ;Patel R;Chisholm KI;Pettingill P;Peck LJ;Sheridan J;Shakir A;Jacobson L;Gutierrez-Mecinas M;Galino J;Walcher J;Kühnemund J;Kuehn H;Sanna MD;Lang B;Clark AJ;Themistocleous AC;Iwagaki N;West SJ;Werynska K;Carroll L;Trendafilova T;Menassa DA;Giannoccaro MP;Coutinho E;Cervellini I;Tewari D;Buckley C;Leite MI;Wildner H;Zeilhofer HU;Peles E;Todd AJ;McMahon SB;Dickenson AH;Lewin GR;Vincent A;Bennett DL
通讯作者：
Bennett DL
影响因子：
2.1
作者：
Enestrom, S;Bengtsson, A;Frodin, T
通讯作者：
Frodin, T
影响因子：
5.5
作者：
Macfarlane, Gary J.;MacDonald, Ross I. R.;Jones, Gareth T.
通讯作者：
Jones, Gareth T.
影响因子：
13.3
作者：
Brummett, Chad M.;Urquhart, Andrew G.;Hassett, Afton L.;Tsodikov, Alex;Hallstrom, Brian R.;Wood, Nathan I.;Williams, David A.;Clauw, Daniel J.
通讯作者：
Clauw, Daniel J.
影响因子：
11.2
作者：
Evdokimov, Dimitar;Frank, Johanna;Uceyler, Nurcan
通讯作者：
Uceyler, Nurcan