Prognostic value of visual residual tumour cells (VRTC) for patients with esophageal squamous cell carcinomas after neoadjuvant therapy followed by surgery.
Prognostic value of visual residual tumour cells (VRTC) for patients with esophageal squamous cell carcinomas after neoadjuvant therapy followed by surgery.
复制标题
新辅助治疗后，手术后，视觉残留肿瘤细胞（VRTC）对食管鳞状细胞癌患者的预后价值。
DOI：
10.1186/s12885-020-07779-0
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发表时间：
2021-02-03
期刊：
影响因子：
3.8
通讯作者：
Hou Y
中科院分区：
文献类型：
--
作者：
Wang X;Wang H;Wang H;Huang J;Wang X;Jiang Z;Tan L;Jiang D;Hou Y
我们采用Becker肿瘤消退分级（TRG）系统和日本TRG系统评估食管鳞状细胞癌（ESCC）患者接受新辅助治疗后手术的视觉残留肿瘤细胞（VRTC）。我们比较了2009 - 2015年间175例ESCC患者的Becker系统和Japanese系统。根据Becker系统，TRG 1a （VRTC 0）、TRG 1b（1-10%）、TRG 2（11-50%）和TRG 3（> 50%）的5年DFS/DSS率分别为70.0%/ 89.3%、53.8%/ 56.7%、43.0%/49.0和42.4%/39.1%。按日本标准，0-1a级（VRTC> 66.6%）、1b级（33.3-66.6%）、2级（1-33.3%）和3级(0)的发病率分别为38.8%/34.1、49.5%/58.7、50.2%/49.0和70.0%/89.3%。两种体系的TRG对患者预后有明显的鉴别作用。Becker系统的TRG （HR 2.662, 95% CI 1.151 ~ 6.157）和淋巴结转移（HR 2.567, 95% CI 1.442 ~ 4.570）是DSS的独立参数。Becker系统和Japanese系统对ESCC患者的风险分层均有优势。推测将1-10% VRTC分成一组可能有助于Becker TRG系统的独立预后意义。因此，除了不同系统的TRG外，病理报告中还可以推荐VRTC的百分比，这样可以使不同研究的结果更具可比性，也便于临床肿瘤学家理解。
We assessed visual residual tumour cells (VRTC) with both Becker’s tumour regression grading (TRG) system and Japanese TRG system in esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant therapy followed by surgery. We compared Becker system and Japanese system in 175 ESCC patients treated between 2009 and 2015. According to Becker system, the 5-year DFS/DSS rates were 70.0%/89.3, 53.8%/56.7, 43.0%/49.0, and 42.4%/39.1% for TRG 1a (VRTC 0), TRG 1b (1–10%), TRG 2 (11–50%), and TRG 3 (> 50%). According to Japanese system, the rates were 38.8%/34.1, 49.5%/58.7, 50.2%/49.0 and 70.0%/89.3% for Grade 0-1a (VRTC> 66.6%), Grade 1b (33.3–66.6%), Grade 2 (1–33.3%) and Grade 3 (0). TRG according to two systems significantly discriminate the patients’ prognosis. TRG according to Becker system (HR 2.662, 95% CI 1.151–6.157), and lymph node metastasis (HR 2.567, 95% CI 1.442–4.570) were independent parameters of DSS. Both Becker and Japanese system had their advantage in risk stratification of these ESCC patients. It was speculated that dividing 1–10% VRTC into a group might contribute to independently prognostic significance of Becker’s TRG system. Therefore, in addition to TRG of different systems, the percentage of VRTC might be recommended in the pathologic report, which could make the results more comparable among different researches, and more understandable for oncologists in the clinical practice.
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影响因子：
8.8
作者：
Schmidt, T.;Sicic, L.;Blank, S.;Becker, K.;Weichert, W.;Bruckner, T.;Parakonthun, T.;Langer, R.;Buechler, M. W.;Siewert, J-R;Lordick, F.;Ott, K.
通讯作者：
Ott, K.
影响因子：
9
作者：
Hoelscher, Arnulf H.;Drebber, Uta;Bollschweiler, Efriede
通讯作者：
Bollschweiler, Efriede
影响因子：
2.5
作者：
Akutsu, Yasunori;Shuto, Kiyohiko;Matsubara, Hisahiro
通讯作者：
Matsubara, Hisahiro
影响因子：
6.2
作者：
Chirieac, LR;Swisher, SG;Wu, TT
通讯作者：
Wu, TT
影响因子：
4.3
作者：
Noble, Fergus;Nolan, Luke;Bateman, Andrew R.
通讯作者：
Bateman, Andrew R.