The Efficacy and Clinical Safety of Various Analgesic Combinations for Post-Operative Pain after Third Molar Surgery: A Systematic Review and Meta-Analysis.
The Efficacy and Clinical Safety of Various Analgesic Combinations for Post-Operative Pain after Third Molar Surgery: A Systematic Review and Meta-Analysis.
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DOI：
10.1371/journal.pone.0127611
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Leung YY
中科院分区：
文献类型：
--
作者：
Au AH;Choi SW;Cheung CW;Leung YY
对随机临床试验进行系统综述和荟萃分析，旨在回答临床问题“哪种镇痛药组合和剂量可能是第三磨牙手术后急性术后疼痛控制最有效和最安全的？"。对计算机数据库和期刊进行了系统检索。由2名独立评审员分3轮进行文献检索和评价。对符合选择标准的下第三磨牙手术后镇痛药联合治疗急性术后疼痛控制相关随机临床试验进行评价，以进入最终审查。最终审查纳入了14项研究，共3521例受试者，10组（17种剂量）镇痛药复方制剂。通过客观疼痛测量值（包括6小时疼痛强度总和（SPID 6）和6小时总疼痛缓解（TOTPAR 6））显示镇痛疗效。报告的镇痛剂组合的SPID 6评分和TOTPAR 6评分范围分别为1.46 - 6.44和3.24 - 10.3。伊立替尼400 mg与盐酸羟考酮5 mg联合治疗的疗效上级（SPID 6：6.44，TOTPAR 6：9.31）。恶心是最常见的不良反应，患病率范围为0- 55%。伊玛目200 mg与咖啡因100 mg或200 mg合用，镇痛效果较好，副作用少。这项系统性综述和荟萃分析可能有助于临床医生选择处方镇痛剂组合用于下第三磨牙手术后的急性术后疼痛控制。在本系统性综述中发现，与本研究中纳入的其他镇痛药联合给药相比，Istarch 400 mg联合盐酸羟考酮5 mg的镇痛疗效上级。
To run a systematic review and meta-analysis of randomized clinical trials aiming to answer the clinical question “which analgesic combination and dosage is potentially the most effective and safe for acute post-operative pain control after third molar surgery?”. A systematic search of computer databases and journals was performed. The search and the evaluations of articles were performed by 2 independent reviewers in 3 rounds. Randomized clinical trials related to analgesic combinations for acute post-operative pain control after lower third molar surgery that matched the selection criteria were evaluated to enter in the final review. Fourteen studies with 3521 subjects, with 10 groups (17 dosages) of analgesic combinations were included in the final review. The analgesic efficacy were presented by the objective pain measurements including sum of pain intensity at 6 hours (SPID6) and total pain relief at 6 hours (TOTPAR6). The SPID6 scores and TOTPAR6 scores of the reported analgesic combinations were ranged from 1.46 to 6.44 and 3.24 – 10.3, respectively. Ibuprofen 400mg with oxycodone HCL 5mg had superior efficacy (SPID6: 6.44, TOTPAR6: 9.31). Nausea was the most common adverse effect, with prevalence ranging from 0-55%. Ibuprofen 200mg with caffeine 100mg or 200mg had a reasonable analgesic effect with fewer side effects. This systematic review and meta-analysis may help clinicians in their choices of prescribing an analgesic combination for acute post-operative pain control after lower third molar surgery. It was found in this systematic review Ibuprofen 400mg combined with oxycodone HCL 5mg has superior analgesic efficacy when compared to the other analgesic combinations included in this study.
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影响因子：
7.4
作者：
Barden, J;Edwards, JE;Moore, RA
通讯作者：
Moore, RA
DOI：
10.1590/s0100-879x2006000900012
发表时间：
2006-09-01
影响因子：
2.3
作者：
Barroso, A.B.;Lima, V.;Moraes, M.E.A.
通讯作者：
Moraes, M.E.A.
影响因子：
7.4
作者：
BJORKMAN, R;HALLMAN, KM;HENNING, M
通讯作者：
HENNING, M
DOI：
10.1016/j.tripleo.2005.04.026
发表时间：
2005-10-01
期刊：
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
影响因子：
--
作者：
Chang, David J;Bird, Steven R;King, Thomas
通讯作者：
King, Thomas
DOI：
10.1016/j.lpm.2009.09.025
发表时间：
2010-05-01
期刊：
Presse medicale (Paris, France : 1983)
影响因子：
--
作者：
Borel, Jean-Francois;Deschaumes, Christophe;Dallel, Radhouane
通讯作者：
Dallel, Radhouane