The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010.
The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010.
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2010年中国上海市不同严重程度手足口病患者细胞因子和趋化因子谱分析
DOI：
10.1371/journal.pntd.0002599
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发表时间：
2013
影响因子：
3.8
通讯作者：
Leng Q
中科院分区：
文献类型：
--
作者：
Zeng M;Zheng X;Wei R;Zhang N;Zhu K;Xu B;Yang CH;Yang CF;Deng C;Pu D;Wang X;Altmeyer R;Leng Q
Background and purpose Systemic upregulation of inflammatory cytokines is characteristic of critical severe hand, foot, and mouth disease (HFMD) with pulmonary edema. Thus, immunomodulatory medicines such as steroids, including methylprednisolone, have been proposed to treat patients with severe HFMD in China, because it is postulated that inflammatory cytokines play a role in the development of severe complications. This study is to further investigate the inflammatory response in the relatively mild HFMD patients, and whether steroid treatment has a beneficial effect on the suppression of inflammation in HFMD patients. Method We measured the levels of 50 kinds of chemokines, cytokines, growth factors and soluble receptors in serum samples from control patients without HFMD and the HFMD patients with or without prior treatment of intravenous methylprednisolone. Results Our present study found that even relatively mild HFMD patients without central nervous system (CNS) complications had elevated serum levels of inflammatory cytokines, including interleukin (IL)-3, IL-6, IL-12p40, and tumor necrosis factor (TNF)-α, which suggested systemic inflammation. In contrast, these patients also have decreased levels of other serum biomarkers, including IL-1Ra, IL-8, IL-16, soluble ICAM-1, CXCL-1, and CCL27. The dysregulation of cytokine and chemokine expression may be involved in CNS complications and unbalanced circulating leukocytes in HFMD patients. Surprisingly, patients treated with methylprednisolone had no difference in the expression levels of HFMD-associated biomarkers instead had slightly increased levels of IL-17A, which was not associated with the occurrence of HFMD. Conclusion Whether steroid treatment has any beneficial effect on the prognosis of HFMD patients requires to be further investigated.
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影响因子：
3.1
作者：
Nguyen Thi Thanh Thao;Nguyen Thi Kim Ngoc;Phan Van Tu;Tran Thi Thuy;Cardosa, Mary Jane;McMinn, Peter Charles;Phuektes, Patchara
通讯作者：
Phuektes, Patchara
影响因子：
4.3
作者：
Confalonieri, Marco;Cifaldi, Rossella;Gabrielli, Marco
通讯作者：
Gabrielli, Marco
DOI：
10.1084/jem.184.3.963
发表时间：
1996-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Loetscher M;Gerber B;Loetscher P;Jones SA;Piali L;Clark-Lewis I;Baggiolini M;Moser B
通讯作者：
Moser B
影响因子：
3.6
作者：
Chang, LY;Hsia, SH;Lin, TY
通讯作者：
Lin, TY
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y