Role of pyroptosis in spinal cord injury and its therapeutic implications.
Role of pyroptosis in spinal cord injury and its therapeutic implications.
复制标题
焦亡在脊髓损伤中的作用及其治疗意义。
DOI：
10.1016/j.jare.2020.08.004
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发表时间：
2021-03
影响因子：
10.7
通讯作者：
Xiao J
中科院分区：
文献类型：
--
作者：
Al Mamun A;Wu Y;Monalisa I;Jia C;Zhou K;Munir F;Xiao J
Neuroinflammation plays a key role in the secondary injury of acute SCI. Pyroptosis is defined as a newly programmed cell death. Recent studies show that pyroptosis play a key role in SCI. Some molecules can significantly inhibit pyroptosis process in SCI. Targeting pyroptosis and inflammasome components can be novel therapeutic strategies for SCI. Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosis is recognized as a new programmed cell death mechanism regulated by the stimulation of caspase-1 and/or caspase-11/-4/-5 signaling pathways with a series of inflammatory responses. Our current review concisely summarizes the potential role of pyroptosis-regulated programmed cell death in SCI, according to several molecular and pathophysiological mechanisms. This review also highlights the targeting of pyroptosis signaling pathways and inflammasome components and its therapeutic implications for the treatment of SCI. Multiple pieces of evidence have illustrated that pyroptosis plays significant roles in cell swelling, plasma membrane lysis, chromatin fragmentation and intracellular pro-inflammatory factors including IL-18 and IL-1β release. In addition, pyroptosis is directly mediated by the recently discovered family of pore-forming protein known as GSDMD. Current investigations have documented that pyroptosis-regulated cell death plays a critical role in the pathogenesis of multiple neurological disorders as well as SCI. Our narrative article suggests that inhibiting the pyroptosis-regulated cell death and inflammasome components could be a promising therapeutic approach for the treatment of SCI in the near future.
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DOI：
10.3233/blc-160052
发表时间：
2016-04-27
期刊：
Bladder cancer (Amsterdam, Netherlands)
影响因子：
--
作者：
Godoy G;Gakis G;Smith CL;Fahmy O
通讯作者：
Fahmy O
影响因子：
29.7
作者：
Brubaker SW;Bonham KS;Zanoni I;Kagan JC
通讯作者：
Kagan JC
影响因子：
11.4
作者：
Cortese-Krott, Miriam M.;Kulakov, Larissa;Oplaender, Christian;Kolb-Bachofen, Victoria;Kroencke, Klaus-D.;Suschek, Christoph V.
通讯作者：
Suschek, Christoph V.
影响因子：
64.8
作者：
Ding, Jingjin;Wang, Kun;Shao, Feng
通讯作者：
Shao, Feng
影响因子：
3.7
作者：
Gustin A;Kirchmeyer M;Koncina E;Felten P;Losciuto S;Heurtaux T;Tardivel A;Heuschling P;Dostert C
通讯作者：
Dostert C