E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans.
E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans.
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DOI：
10.3390/biom12020224
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发表时间：
2022-01-27
期刊：
影响因子：
5.5
通讯作者：
Baron M
中科院分区：
文献类型：
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作者：
Revici R;Hosseini-Alghaderi S;Haslam F;Whiteford R;Baron M
Noch是一种发育受体，在后生动物的进化中保守，在许多发育环境中调节细胞的命运、增殖和生存，也调节成年生物的组织更新和修复。Notch是通过蛋白水解性去除其胞外结构域并随后释放其细胞内结构域而激活的，然后该结构域作为转录因子复合体的一部分在细胞核内发挥作用。存在许多调节机制来调节这一核心信号机制的幅度、持续时间和空间模式。在果蝇中，Deltex(Dx)和Dx的抑制者(SU(Dx))是E3泛素连接酶，它们与Notch胞内结构域相互作用，调节其内向转运，影响配体依赖和非配体依赖的信号激活。Dx和SU(Dx)的同系物也被证明与四种哺乳动物Notch蛋白和其他靶底物中的一种或多种相互作用。研究表明，这些Notch监管者的角色相似、专业化和多样化。本文综述了脊椎动物Dx和SU(Dx)相关蛋白的研究现状，概述了它们的各种作用，并讨论了它们在细胞命运调控和疾病中的作用。
Notch is a developmental receptor, conserved in the evolution of the metazoa, which regulates cell fate proliferation and survival in numerous developmental contexts, and also regulates tissue renewal and repair in adult organisms. Notch is activated by proteolytic removal of its extracellular domain and the subsequent release of its intracellular domain, which then acts in the nucleus as part of a transcription factor complex. Numerous regulatory mechanisms exist to tune the amplitude, duration and spatial patterning of this core signalling mechanism. In Drosophila, Deltex (Dx) and Suppressor of dx (Su(dx)) are E3 ubiquitin ligases which interact with the Notch intracellular domain to regulate its endocytic trafficking, with impacts on both ligand-dependent and ligand-independent signal activation. Homologues of Dx and Su(dx) have been shown to also interact with one or more of the four mammalian Notch proteins and other target substrates. Studies have shown similarities, specialisations and diversifications of the roles of these Notch regulators. This review collates together current research on vertebrate Dx and Su(dx)-related proteins, provides an overview of their various roles, and discusses their contributions to cell fate regulation and disease.
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