mini-MED: study protocol for a randomized, multi-intervention, semi-controlled feeding trial of a Mediterranean-amplified vs. habitual Western dietary pattern for the evaluation of food-specific compounds and cardiometabolic health.
mini-MED: study protocol for a randomized, multi-intervention, semi-controlled feeding trial of a Mediterranean-amplified vs. habitual Western dietary pattern for the evaluation of food-specific compounds and cardiometabolic health.
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DOI：
10.1186/s13063-024-07939-8
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发表时间：
2024-02-02
期刊：
影响因子：
2.5
通讯作者：
Krebs, Nancy F.
中科院分区：
文献类型：
--
作者：
Hill, Emily B.;Tang, Minghua;Long, Julie M.;Kemp, Jennifer F.;Westcott, Jamie L.;Hendricks, Audrey E.;Reisdorph, Nichole A.;Campbell, Wayne W.;Krebs, Nancy F.
关键词：
饮食是影响慢性病风险的最有影响力的生活方式因素之一。营养代谢组学是代谢组学在营养研究中的应用，可以检测食物特异性化合物（FSC），这些化合物可用于将饮食模式（如地中海式（MED）饮食）与健康联系起来。这项验证研究是基于对受控喂养MED干预的分析，我们的团队从八种食物中鉴定出FSC，这些食物可以在食用后的生物标本中检测到，因此可以作为食物摄入的生物标志物。不习惯食用MED饮食模式的超重/肥胖个体将完成16周的等热量饮食干预的随机、多重干预、半对照喂养研究：（1）MED扩大饮食模式，包含来自八种MED目标食物的500 kcal/天：鳄梨、罗勒、樱桃、鹰嘴豆、燕麦、红甜椒、核桃和蛋白质源（鲑鱼或未加工的瘦牛肉之间交替），和（2）习惯/西方饮食模式，包含500千卡/天的六种非MED目标食物：奶酪蛋糕、巧克力冻酸奶、精制谷物面包、酸奶油、白色土豆和未加工的瘦牛肉。在2周的洗脱期后，参与者完成4周的干预期，在基线和干预第4、8、12和16周进行生物样本采样和结果评估。主要结果是从基线到每个干预期结束时，参与者生物标本中来自八种MED目标食物的FSC相对丰度的变化。次要结局包括心脏代谢健康指标、炎症标志物和脂肪因子的平均变化。探索性结果包括肠道微生物群的多样性和群落组成的变化。我们的逐步战略，从确定整个饮食和生物标本中的FSC开始，然后将其与健康指标相关联，将导致改进饮食模式评估方法，并更好地了解食物与健康之间的关系。这项研究将作为验证候选食物摄入生物标志物的第一步，并允许评估与心脏代谢健康的关系。食物摄入生物标志物的识别对未来的研究至关重要，并对许多慢性疾病的健康促进和疾病预防具有重要意义。在www.example.com注册：NCT 05500976;注册日期：2022年8月15日。
Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compounds (FSCs) that can be used to connect dietary patterns, such as a Mediterranean-style (MED) diet, to health. This validation study is based upon analyses from a controlled feeding MED intervention, where our team identified FSCs from eight foods that can be detected in biospecimens after consumption and may therefore serve as food intake biomarkers. Individuals with overweight/obesity who do not habitually consume a MED dietary pattern will complete a 16-week randomized, multi-intervention, semi-controlled feeding study of isocaloric dietary interventions: (1) MED-amplified dietary pattern, containing 500 kcal/day from eight MED target foods: avocado, basil, cherry, chickpea, oat, red bell pepper, walnut, and a protein source (alternating between salmon or unprocessed, lean beef), and (2) habitual/Western dietary pattern, containing 500 kcal/day from six non-MED target foods: cheesecake, chocolate frozen yogurt, refined grain bread, sour cream, white potato, and unprocessed, lean beef. After a 2-week washout, participants complete four, 4-week intervention periods, with biospecimen sampling and outcome assessments at baseline and at intervention weeks 4, 8, 12, and 16. The primary outcome is change in the relative abundance of FSCs from the eight MED target foods in participant biospecimens from baseline to the end of each intervention period. Secondary outcomes include mean change in cardiometabolic health indicators, inflammatory markers, and adipokines. Exploratory outcomes include change in diversity and community composition of the gut microbiota. Our stepwise strategy, beginning with identification of FSCs in whole diets and biospecimens, followed by relating these to health indicators will lead to improved methodology for assessment of dietary patterns and a better understanding of the relationship between food and health. This study will serve as a first step toward validating candidate food intake biomarkers and allow for assessment of relationships with cardiometabolic health. The identification of food intake biomarkers is critical to future research and has implications spanning health promotion and disease prevention for many chronic conditions. Registered at ClinicalTrials.gov: NCT05500976; Date of registration: August 15, 2022.
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影响因子：
3.7
作者：
Son JS;Khair S;Pettet DW 3rd;Ouyang N;Tian X;Zhang Y;Zhu W;Mackenzie GG;Robertson CE;Ir D;Frank DN;Rigas B;Li E
通讯作者：
Li E
基于REDCAP的电子同意模型（ECONTENT）：朝着更个性化的同意迈进。
影响因子：
2.6
作者：
Lawrence CE;Dunkel L;McEver M;Israel T;Taylor R;Chiriboga G;Goins KV;Rahn EJ;Mudano AS;Roberson ED;Chambless C;Wadley VG;Danila MI;Fischer MA;Joosten Y;Saag KG;Allison JJ;Lemon SC;Harris PA
通讯作者：
Harris PA
DOI：
10.1093/ajcn/nqy075
发表时间：
2018-07-01
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
O'Connor LE;Paddon-Jones D;Wright AJ;Campbell WW
通讯作者：
Campbell WW
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.