Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.
Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.
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DOI：
10.1371/journal.pone.0074738
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Jang KY
中科院分区：
文献类型：
--
作者：
Kim JR;Moon YJ;Kwon KS;Bae JS;Wagle S;Yu TK;Kim KM;Park HS;Lee JH;Moon WS;Lee H;Chung MJ;Jang KY
近年来，SIRT1和缺失在乳腺癌1(DBC1)中的作用已被广泛研究，并已证明它们与许多人类肿瘤有关。然而，它们对软组织肉瘤的临床意义还没有得到检验。本研究探讨SIRT1、Dbc1、P53、β-catenin、Cyclin D1和Ki67在10 4例软组织肉瘤中的表达及其预后意义。结果：SIRT1、Dbc1、P53、β-catenin和细胞周期蛋白D1在肉瘤中的表达分别为71%、74%、53%、48%和73%。SIRT1、Dbc1、P53、β-catenin和细胞周期蛋白D1的表达与高临床分期、高组织学分级、有丝分裂数增多和远处转移等晚期临床病理参数显著相关。单因素分析显示，SIRT1、Dbc1、P53、β-catenin、细胞周期蛋白D1和Ki67的阳性表达均预示着较短的总生存期和无事件生存期。多变量分析显示，SIRT1的表达是肉瘤患者总生存期和无事件生存期的独立预后指标。综上所述，本研究表明SIRT1和DBC1相关通路可能参与了软组织肉瘤的进展，可作为肉瘤患者临床上有意义的预后指标。此外，SIRT1和DBC1相关通路可能成为肉瘤治疗的新靶点。
Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas. RESULTS: Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas.
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影响因子：
11.2
作者：
Chu, F;Chou, PM;Rebbaa, A
通讯作者：
Rebbaa, A
DOI：
10.1093/jnci/86.7.549
发表时间：
1994-04-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
DROBNJAK, M;LATRES, E;CORDONCARDO, C
通讯作者：
CORDONCARDO, C
乳腺癌 1 中删除了一种新型雄激素受体 (AR) 共激活剂，可促进 AR DNA 结合活性
影响因子：
4.8
作者：
Fu, Junjiang;Jiang, Jun;Wong, Jiemin
通讯作者：
Wong, Jiemin
DOI：
10.1073/pnas.0911325107
发表时间：
2010-05-18
影响因子：
11.1
作者：
Holloway, Kimberly R.;Calhoun, Tara N.;Pruitt, Kevin
通讯作者：
Pruitt, Kevin
影响因子：
3.3
作者：
Dickson, Brendan C.;Riddle, Nicole D.;Zhang, Paul J.
通讯作者：
Zhang, Paul J.