Prolonged gut microbial alterations in post‐transplant survivors of allogeneic haematopoietic stem cell transplantation
Prolonged gut microbial alterations in post‐transplant survivors of allogeneic haematopoietic stem cell transplantation
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异基因造血干细胞移植的移植后幸存者肠道微生物的长期改变
DOI：
10.1111/bjh.18574
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发表时间：
2022
影响因子：
6.5
通讯作者：
Hosen Naoki
中科院分区：
文献类型：
--
作者：
Hino Akihisa;Fukushima Kentaro;Kusakabe Shinsuke;Ueda Tomoaki;Sudo Takao;Fujita Jiro;Motooka Daisuke;Takeda Aya K.;Shinozaki Natsuko O.;Watanabe Satoshi;Yokota Takafumi;Shibayama Hirohiko;Nakamura Shota;Hosen Naoki
据报道，肠道微生物群的生态失调会增加异基因造血干细胞移植（allo-HSCT）后的早期并发症。然而，目前尚不清楚肠道微生物的改变是否在晚期并发症中持续存在，如慢性移植物抗宿主病（cGVHD）或继发性癌症。在这里，我们分析了59名患者的肠道微生物群，这些患者在allo‐HSCT后存活了1-21.7年（中位数，6.4年）。长期存活者的肠道微生物多样性低于年龄和性别匹配的健康对照组。这种减少的多样性反映在产丁酸细菌的丰度减少。有3级急性移植物抗宿主病（aGVHD）病史的患者比有1-2级或非aGVHD病史的患者表现出更高的韦荣球菌丰度。粪杆菌的丰度仅在有限的cGVHD病例中没有下降。此外，继发性癌症组中的微生物结构与非继发性癌症组中的微生物结构显著不同（p< 0.05）。这项研究首次表明，在allo‐HSCT后出院后10年的生命周期内存在微生物生态失调。我们的研究结果表明，这些长期的肠道微生物变化可能与移植后幸存者晚期并发症的发展和恶化有关。
Dysbiosis of the gut microbiota has been reported to increase early complications after allogeneic haematopoietic stem cell transplantation (allo‐HSCT). However, it remains unclear whether gut microbial alterations persist during late complications, such as chronic graft‐versus‐host disease (cGVHD) or secondary cancers. Here, we analysed the gut microbiota of 59 patients who survived for 1–21.7 years (median, 6.4 years) after allo‐HSCT. Long‐term survivors showed lower gut microbial diversity than the age‐ and sex‐matched healthy controls. This decreased diversity was reflected in the reduced abundance of the butyrate‐producing bacteria. Patients with a history of grade 3 acute graft‐versus‐host disease (aGVHD) exhibited higherVeillonellaabundance than patients with a history of grade 1–2 or non‐aGVHD cases. The abundance ofFaecalibacteriumshowed no decrease only in limited cGVHD cases. Additionally, the microbial structure in the secondary cancer group was significantly different (p< 0.05) from that in the non‐secondary cancer group. This study is the first to show that microbial dysbiosis is present over a 10‐year lifetime after discharge following allo‐HSCT. Our results suggest that these prolonged gut microbial alterations may be associated with the development and exacerbation of late complications in post‐transplant survivors.
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影响因子：
4.6
作者：
Hamada R;Arai Y;Kondo T;Harada K;Murao M;Miyasaka J;Yoshida M;Yonezawa H;Nankaku M;Ouchi S;Kitakubo W;Wadayama T;Kanda J;Takaori-Kondo A;Ikeguchi R;Matsuda S
通讯作者：
Matsuda S
影响因子：
20.3
作者：
Taur, Ying;Jenq, Robert R.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
影响因子：
20.3
作者：
Rizzo, J. Douglas;Curtis, Rochelle E.;Deeg, H. Joachim
通讯作者：
Deeg, H. Joachim
影响因子：
11.8
作者：
Meedt, Elisabeth;Hiergeist, Andreas;Weber, Daniela
通讯作者：
Weber, Daniela
影响因子：
39.2
作者：
Kolb, HJ;Socié, G;Prentice, HG
通讯作者：
Prentice, HG