Clinical Properties and Diagnostic Methods of COVID-19 Infection in Pregnancies: Meta-Analysis.
Clinical Properties and Diagnostic Methods of COVID-19 Infection in Pregnancies: Meta-Analysis.
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DOI：
10.1155/2020/1708267
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发表时间：
2020
影响因子：
--
通讯作者：
Acar-Bolat B
中科院分区：
文献类型：
--
作者：
Uygun-Can B;Acar-Bolat B
我们旨在通过荟萃分析所有已发表的回顾性研究，总结可靠的医学证据，这些研究检查了基于临床症状、分子（RT-PCR）诊断和孕妇特征性CT成像特征检测严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）的数据。使用MEDLINE、PubMed、Scopus、ISI Web of Science、ClinicalKey和CINAHL数据库选择研究。截止到2020年5月1日，共收到论文384篇。通过全文评估，我们选择了12篇涵盖所有相关数据的回顾性文章。在这些文章的范围内，共有181例感染SARS-CoV-2的孕妇被纳入meta分析。结果显示，妊娠期SARS-CoV-2感染病例的所有临床特征中，发热发生率为38.1% (95% CI: 14.2 ~ 65%)，咳嗽发生率为22% （95% CI: 10.8 ~ 35.2%）。因此，发烧和咳嗽是孕妇感染SARS-CoV-2最常见的症状，91.8% （95% CI: 76.7-99.9%）的RT-PCR结果为阳性。CT异常阳性率为97.9% （95% CI: 94.2 ~ 99.9%）。没有死亡病例。然而，随着这种病毒在全球传播，不应忽视的是，孕妇和高危人群的发病率将会增加。RT-PCR和CT可以一起用于准确和安全的诊断。总之，这些发现将为当前关于孕妇SARS-CoV-2感染的临床特征和正确检测的研究提供重要指导，以及是否需要创建需要使用病毒药物的应急表。
We aimed to summarize reliable medical evidence by the meta-analysis of all published retrospective studies that examined data based on the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by clinical symptoms, molecular (RT-PCR) diagnosis, and characteristic CT imaging features in pregnant women. The MEDLINE, PubMed, Scopus, ISI Web of Science, ClinicalKey, and CINAHL databases were used to select the studies. Then, 384 articles were received, including the studies until 01/May/2020. As a result of the full-text evaluation, 12 retrospective articles covering all the data related were selected. A total of 181 pregnant cases with SARS-CoV-2 infections were included in the meta-analysis within the scope of these articles. According to the results, the incidence of fever was 38.1% (95% CI: 14.2-65%) and cough was 22% (95% CI: 10.8-35.2%) among all clinical features of pregnant cases with SARS-CoV-2 infection. So, fever and cough are the most common symptoms in pregnant cases with SARS-CoV-2 infection, and 91.8% (95% CI: 76.7-99.9%) of RT-PCR results are positive. Moreover, abnormal CT incidence is 97.9% (95% CI: 94.2-99.9%) positive. No case was death. However, as this virus spreads globally, it should not be overlooked that the incidence will increase in pregnant women and maybe in the risky group. RT-PCR and CT can be used together in an accurate and safe diagnosis. In conclusion, these findings will provide important guidance for current studies regarding the clinical features and correct detection of SARS-CoV-2 infection in pregnant women, as well as whether it will create emergency tables that will require the use of a viral drug.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
6.3
作者：
Barendregt, Jan J.;Doi, Suhail A.;Vos, Theo
通讯作者：
Vos, Theo
影响因子：
168.9
作者：
Chen, Huijun;Guo, Juanjuan;Zhang, Yuanzhen
通讯作者：
Zhang, Yuanzhen