Beyond Hemoglobin: Screening for Malaria Host Factors.
Beyond Hemoglobin: Screening for Malaria Host Factors.
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除血红蛋白外：筛查疟疾宿主因素。
DOI：
10.1016/j.tig.2017.11.004
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Egan ES
中科院分区：
文献类型：
--
作者：
Egan ES
严重疟疾是由顶复门寄生虫恶性疟原虫引起的，导致全球发病率和死亡率显着增加，特别是在幼儿和孕妇中。恶性疟原虫在临床疾病期间专门感染人类红细胞，并且几种天然红细胞多态性可以预防严重疟疾。由于红细胞已去核并且缺乏 DNA，因此了解疟疾感染的红细胞决定因素的遗传方法历来受到限制。本综述重点介绍了利用造血干细胞促进疟疾宿主因子基因筛查的最新进展。尽管挑战仍然存在，但这种方法有望获得对疟疾宿主与病原体相互作用的新见解。
Severe malaria is caused by the Apicomplexan parasite Plasmodium falciparum, and results in significant global morbidity and mortality, particularly among young children and pregnant women. P. falciparum exclusively infects human erythrocytes during clinical illness, and several natural erythrocyte polymorphisms are protective against severe malaria. Since erythrocytes are enucleated and lack DNA, genetic approaches to understand erythrocyte determinants of malaria infection have historically been limited. This review highlights recent advances in the use of hematopoietic stem cells to facilitate genetic screening for malaria host factors. While challenges still exist, this approach holds promise for gaining new insights into host-pathogen interactions in malaria.
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影响因子：
29
作者：
Arroyo JD;Jourdain AA;Calvo SE;Ballarano CA;Doench JG;Root DE;Mootha VK
通讯作者：
Mootha VK
影响因子：
46.9
作者：
Hendel A;Bak RO;Clark JT;Kennedy AB;Ryan DE;Roy S;Steinfeld I;Lunstad BD;Kaiser RJ;Wilkens AB;Bacchetta R;Tsalenko A;Dellinger D;Bruhn L;Porteus MH
通讯作者：
Porteus MH
影响因子：
30.8
作者：
Jallow, Muminatou;Teo, Yik Ying;Small, Kerrin S.;Rockett, Kirk A.;Deloukas, Panos;Clark, Taane G.;Kivinen, Katja;Bojang, Kalifa A.;Conway, David J.;Pinder, Margaret;Sirugo, Giorgio;Sisay-Joof, Fatou;Usen, Stanley;Auburn, Sarah;Bumpstead, Suzannah J.;Campino, Susana;Coffey, Alison;Dunham, Andrew;Fry, Andrew E.;Green, Angela;Gwilliam, Rhian;Hunt, Sarah E.;Inouye, Michael;Jeffreys, Anna E.;Mendy, Alieu;Palotie, Aarno;Potter, Simon;Ragoussis, Jiannis;Rogers, Jane;Rowlands, Kate;Somaskantharajah, Elilan;Whittaker, Pamela;Widden, Claire;Donnelly, Peter;Howie, Bryan;Marchini, Jonathan;Morris, Andrew;SanJoaquin, Miguel;Achidi, Eric Akum;Agbenyega, Tsiri;Allen, Angela;Amodu, Olukemi;Corran, Patrick;Djimde, Abdoulaye;Dolo, Amagana;Doumbo, Ogobara K.;Drakeley, Chris;Dunstan, Sarah;Evans, Jennifer;Farrar, Jeremy;Fernando, Deepika;Hien, Tran Tinh;Horstmann, Rolf D.;Ibrahim, Muntaser;Karunaweera, Nadira;Kokwaro, Gilbert;Koram, Kwadwo A.;Lemnge, Martha;Makani, Julie;Marsh, Kevin;Michon, Pascal;Modiano, David;Molyneux, Malcolm E.;Mueller, Ivo;Parker, Michael;Peshu, Norbert;Plowe, Christopher V.;Puijalon, Odile;Reeder, John;Reyburn, Hugh;Riley, Eleanor M.;Sakuntabhai, Anavaj;Singhasivanon, Pratap;Sirima, Sodiomon;Tall, Adama;Taylor, Terrie E.;Thera, Mahamadou;Troye-Blomberg, Marita;Williams, Thomas N.;Wilson, Michael;Kwiatkowski, Dominic P.
通讯作者：
Kwiatkowski, Dominic P.
影响因子：
3
作者：
Hedrick PW
通讯作者：
Hedrick PW
影响因子：
64.8
作者：
Malaria Genomic Epidemiology Network;Band G;Rockett KA;Spencer CC;Kwiatkowski DP
通讯作者：
Kwiatkowski DP