Activating transcription factor-2 in survival mechanisms in head and neck carcinoma cells.
Activating transcription factor-2 in survival mechanisms in head and neck carcinoma cells.
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DOI：
10.1002/hed.21648
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发表时间：
2011-11
影响因子：
2.9
通讯作者：
Gorti, Goutham Krishna
中科院分区：
文献类型：
--
作者：
Duffey, Dianne;Dolgilevich, Svetlana;Razzouk, Sleiman;Li, Lina;Green, Ross;Gorti, Goutham Krishna
Activating transcription factor-2 (ATF2) is associated with tumor progression, but is not well-studied in head and neck squamous cell carcinoma (HNSCC). Its effects in stress and its importance in other survival mechanisms were studied. ATF2 expression and nuclear activation were confirmed in HNSCC. Following modulation of ATF2, in vitro effects on proliferation and chemosensitivity were studied. Effects on in vivo tumor growth and Interleukin 8 (IL-8) expression were determined. Tumor Necrosis Factor (TNF) alpha treatment was used to further evaluate cytokine production and chemosensitivity. Reductions of ATF2 resulted in significant nuclear p-ATF2 activation, cisplatin resistance and augmented IL-8 expression without affecting in vivo tumor growth. In this setting, TNF increases p-p38 phosphorylation and chemosensitivity while further enhancing IL-8 production. Our data suggest regulatory roles for ATF2 in TNF-related mechanisms of HNSCC. Its perturbation and nuclear activation are associated with significant effects on survival and cytokine production.
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影响因子：
11.4
作者：
LIVINGSTONE, C;PATEL, G;JONES, N
通讯作者：
JONES, N
DOI：
10.1073/pnas.88.9.3720
发表时间：
1991-05-01
影响因子：
11.1
作者：
HAI, T;CURRAN, T
通讯作者：
CURRAN, T
影响因子：
8
作者：
Sánchez-Perez, I;Murguía, JR;Perona, R
通讯作者：
Perona, R
影响因子：
11.2
作者：
Bhoumik, A;Gangi, L;Ronai, Z
通讯作者：
Ronai, Z
DOI：
10.1016/j.ijrobp.2007.05.080
发表时间：
2007-01-01
影响因子：
7
作者：
Bauer, Joshua A.;Kumar, Bhavna;Bradford, Carol R.
通讯作者：
Bradford, Carol R.