Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases.

Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases.
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肥胖及相关代谢疾病中肠道微生物群与脂肪组织之间的相互作用

DOI:
10.3389/fendo.2022.908868
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发表时间:
2022
影响因子:
5.2
通讯作者:
Hu, Fang
Hu, Fang
中科院分区:
医学2区
文献类型:
--
作者:
Wu, Dan;Wang, Huiying;Xie, Lijun;Hu, Fang

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The rapid increase of obesity and associated diseases has become a major global health problem. Adipose tissues are critical for whole-body homeostasis. The gut microbiota has been recognized as a significant environmental factor in the maintenance of energy homeostasis and host immunity. A growing body of evidence suggests that the gut microbiota regulates host metabolism through a close cross-talk with adipose tissues. It modulates energy expenditure and alleviates obesity by promoting energy expenditure, but it also produces specific metabolites and structural components that may act as the central factors in the pathogenesis of inflammation, insulin resistance, and obesity. Understanding the relationship between gut microbiota and adipose tissues may provide potential intervention strategies to treat obesity and associated diseases. In this review, we focus on recent advances in the gut microbiota and its actions on adipose tissues and highlight the joint actions of the gut microbiota and adipose tissue with each other in the regulation of energy metabolism.
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