Role of mitochondria in mediating chondrocyte response to mechanical stimuli.
Role of mitochondria in mediating chondrocyte response to mechanical stimuli.
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DOI：
10.1016/j.lfs.2020.118602
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发表时间：
2020-12-15
期刊：
影响因子：
6.1
通讯作者：
Lin H
中科院分区：
文献类型：
--
作者：
He Y;Makarczyk MJ;Lin H
作为关节炎最常见的形式，骨关节炎（OA）已成为受影响人群中严重关节疼痛、身体残疾和生活质量受损的主要原因。迄今为止，OA的确切发病机制尚未完全阐明，这导致开发有效治疗的重大障碍，例如在过去几十年中未能找到疾病修饰OA药物（DMOAD）。鉴于关节主要显示承重和运动支持功能，机械应力是OA的主要风险因素之一也就不足为奇了。然而，机械应力和OA发病/进展之间的内在联系还有待探讨。软骨细胞是软骨中唯一的细胞类型，线粒体是一种广泛存在的细胞器，参与三磷酸腺苷（adenosine triphosphate，ATP）的合成和细胞代谢等复杂的生物学调节过程，对软骨细胞的存活和功能发挥起着重要的调控作用。在骨关节炎软骨细胞中也观察到线粒体功能障碍。在这篇综述中，我们系统地总结了OA进展过程中软骨细胞的线粒体改变，并讨论了我们最近在了解线粒体在介导机械应力相关的软骨细胞骨关节炎改变中的潜在作用方面的进展。特别是，我们提出了可能调控这一过程的潜在信号通路，为预防和治疗机械应力相关OA提供了新的观点和治疗靶点。
As the most common form of arthritis, osteoarthritis (OA) has become a major cause of severe joint pain, physical disability, and quality of life impairment in the affected population. To date, precise pathogenesis of OA has not been fully clarified, which leads to significant obstacles in developing efficacious treatments such as failures in finding disease-modifying OA drugs (DMOADs) in the last decades. Given that diarthrodial joints primarily display the weight-bearing and movement-supporting function, it is not surprising that mechanical stress represents one of the major risk factors for OA. However, the inner connection between mechanical stress and OA onset/progression has yet to be explored. Mitochondrion, a widespread organelle involved in complex biological regulation processes such as adenosine triphosphate (ATP) synthesis and cellular metabolism, is believed to have a controlling role in the survival and function implement of chondrocytes, the singular cell type within cartilage. Mitochondrial dysfunction has also been observed in osteoarthritic chondrocytes. In this review, we systemically summarize mitochondrial alterations in chondrocytes during OA progression and discuss our recent progress in understanding the potential role of mitochondria in mediating mechanical stress-associated osteoarthritic alterations of chondrocytes. In particular, we propose the potential signaling pathways that may regulate this process, which provide new views and therapeutic targets for the prevention and treatment of mechanical stress-associated OA.
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影响因子：
7
作者：
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通讯作者：
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影响因子：
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发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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