Modeling and analysis of transport in the mammary glands
Modeling and analysis of transport in the mammary glands
复制标题
乳腺运输的建模和分析
作者：
Ana Quezada;K. Vafai
在这项工作中，分析了三种毒素从血流进入乳腺导管的运输。将模型预测与文献中的实验数据进行了比较。该模型的实用性在于它有可能提高我们对毒素转运作为乳腺癌前置因素的理解。这项工作是基于一个多层传输模型来分析母乳中存在的毒素。与其他采样策略相比，母乳使我们能够了解毒素一旦进入哺乳妇女的血液中就会大量传输。提出的多层模型描述了咖啡因、滴滴涕和西咪替丁的转运。所进行的分析考虑了每种毒素的独特传输机制。我们的模型预测了毒素和/或药物在乳腺内的运动以及它们在组织中的生物积累。
The transport of three toxins moving from the blood stream into the ducts of the mammary glands is analyzed in this work. The model predictions are compared with experimental data from the literature. The utility of the model lies in its potential to improve our understanding of toxin transport as a pre-disposing factor to breast cancer. This work is based on a multi-layer transport model to analyze the toxins present in the breast milk. The breast milk in comparison with other sampling strategies allows us to understand the mass transport of toxins once inside the bloodstream of breastfeeding women. The multi-layer model presented describes the transport of caffeine, DDT and cimetidine. The analysis performed takes into account the unique transport mechanisms for each of the toxins. Our model predicts the movement of toxins and/or drugs within the mammary glands as well as their bioaccumulation in the tissues.
影响因子：
2.7
作者：
Péchoux, C;Gudjonsson, T;Petersen, OW
通讯作者：
Petersen, OW
哺乳期间西咪替丁的药代动力学：西咪替丁转运至大鼠和兔奶中的物种差异。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
McNamara,PJ;Burgio,D;Yoo,SD
通讯作者：
Yoo,SD