Atrial Cardiopathy and Sympatho-Vagal Imbalance in Cryptogenic Stroke: Pathogenic Mechanisms and Effects on Electrocardiographic Markers.

Atrial Cardiopathy and Sympatho-Vagal Imbalance in Cryptogenic Stroke: Pathogenic Mechanisms and Effects on Electrocardiographic Markers.
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DOI:
10.3389/fneur.2018.00469
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发表时间:
2018
影响因子:
3.4
通讯作者:
Martini G
Martini G
中科院分区:
医学3区
文献类型:
--
作者:
Acampa M;Lazzerini PE;Martini G

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近年来,心房心脏病已成为隐源性卒中的可能致病机制,许多心电图(ECG)标志物已被提出,以便在早期检测心房底物的改变。自主神经系统(ANS)在决定心房心肌细胞显著和异质的电生理变化中起着众所周知的作用,这些变化促进了心栓性卒中中心房颤动的发作。相反,ANS在心房心脏病和隐源性卒中中的作用以及ANS对心房功能障碍心电图标志物的影响则鲜为人知。在这篇文章中,我们回顾了ANS功能障碍和心房心脏病作为隐源性卒中可能的致病因素的证据。
Recently, atrial cardiopathy has emerged as possible pathogenic mechanism in cryptogenic stroke and many electrocardiographic (ECG) markers have been proposed in order to detect an altered atrial substrate at an early stage. The autonomic nervous system (ANS) plays a well-known role in determining significant and heterogeneous electrophysiological changes of atrial cardiomyocytes, that promote atrial fibrillation episodes in cardioembolic stroke. Conversely, the role of ANS in atrial cardiopathy and cryptogenic stroke is less known, as well as ANS effects on ECG markers of atrial dysfunction. In this paper, we review the evidence linking ANS dysfunction and atrial cardiopathy as a possible pathogenic factor in cryptogenic stroke.
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