Cyclic AMP sensor EPAC proteins and energy homeostasis.
Cyclic AMP sensor EPAC proteins and energy homeostasis.
复制标题
环状AMP传感器EPAC蛋白和能量稳态。
DOI：
10.1016/j.tem.2013.10.004
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发表时间：
2014-02
影响因子：
10.9
通讯作者：
Cheng, Xiaodong
中科院分区：
文献类型：
--
作者：
Almahariq, Muayad;Mei, Fang C.;Cheng, Xiaodong
关键词：
The pleotropic second messenger cAMP plays a critical role in mediating the effects of various hormones on metabolism. The major intracellular functions of cAMP are transduced by protein kinase A (PKA) and exchange proteins directly activated by cAMP (EPACs). The latter act as guanine nucleotide exchange factors for the RAS-like small G-proteins Rap1 and Rap2. While the role of PKA in regulating energy balance has been extensively studied, EPACs’ impact remains relatively enigmatic. This review summarizes recent genetic and pharmacological studies concerning EPACs’ involvement in glucose homeostasis and energy balance, through regulation of leptin and insulin signaling pathways. Additionally, the development of small molecule EPAC-specific modulators and their therapeutic potential for the treatment of diabetes and obesity are discussed.
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影响因子：
29
作者：
Al-Qassab H;Smith MA;Irvine EE;Guillermet-Guibert J;Claret M;Choudhury AI;Selman C;Piipari K;Clements M;Lingard S;Chandarana K;Bell JD;Barsh GS;Smith AJ;Batterham RL;Ashford ML;Vanhaesebroeck B;Withers DJ
通讯作者：
Withers DJ
影响因子：
2.7
作者：
Chen, Haijun;Tsalkova, Tamara;Mei, Fang C.;Hu, Yaohua;Cheng, Xiaodong;Zhou, Jia
通讯作者：
Zhou, Jia
影响因子：
15.9
作者：
Banno, Ryoichi;Zimmer, Derek;Bence, Kendra K.
通讯作者：
Bence, Kendra K.
DOI：
10.1152/ajpendo.90617.2008
发表时间：
2008-12-01
影响因子：
5.1
作者：
Andrikopoulos, Sofianos;Blair, Amy R.;Proietto, Joseph
通讯作者：
Proietto, Joseph
影响因子：
4.8
作者：
Chepurny, Oleg G.;Leech, Colin A.;Holz, George G.
通讯作者：
Holz, George G.