Translating genome-wide association findings into new therapeutics for psychiatry.

Translating genome-wide association findings into new therapeutics for psychiatry.
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DOI:
10.1038/nn.4411
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发表时间:
2016-10-26
影响因子:
25
通讯作者:
Edenberg HJ
Edenberg HJ
中科院分区:
医学1区
文献类型:
--
作者:
Breen G;Li Q;Roth BL;O'Donnell P;Didriksen M;Dolmetsch R;O'Reilly PF;Gaspar HA;Manji H;Huebel C;Kelsoe JR;Malhotra D;Bertolino A;Posthuma D;Sklar P;Kapur S;Sullivan PF;Collier DA;Edenberg HJ

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精神病学中的全基因组关联研究(GWAS),一旦达到足够的样本量和能力,就已经取得了巨大的成功。精神病学基因组联合会(PGC)的目标是进行大规模分析,样本规模将在未来5年内增长到(累计)100万人。这应该会导致PGC研究的九种精神疾病的数百种常见基因变异的新发现。GWAS发现的新靶点有可能重新启动基本上停滞不前的精神药物开发管道,将Gwas的研究结果转化为临床是最近资助的PGC第三阶段的一个关键目标。这并不是没有相当大的技术挑战。这些方法补充了GWAS研究的其他主要目的,即风险预测方法,以改进检测、鉴别诊断和临床试验设计。本文概述了研究的动机、技术和分析问题,以及将PGC3的发现转化为新疗法的计划。
Genome-wide association studies (GWAS) in psychiatry, once they reach sufficient sample size and power, have been enormously successful. The Psychiatric Genomics Consortium (PGC) aims for mega-analyses with sample sizes that will grow to (cumulatively) >1 million individuals in the next 5 years. This should lead to hundreds of new findings for common genetic variants across nine psychiatric disorders studied by the PGC. The new targets discovered by GWAS have the potential to restart largely stalled psychiatric drug development pipelines, and the translation of GWAS findings into the clinic is a key aim of the recently funded phase 3 of the PGC. This is not without considerable technical challenges. These approaches complement the other main aim of GWAS studies on risk prediction approaches for improving detection, differential diagnosis, and clinical trial design. This paper outlines the motivations, technical and analytical issues, and the plans for translating PGC3 findings into new therapeutics.
DOI: 10.1177/0269881116653109
发表时间: 2016-08-01
影响因子: 4.1
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de Jong, Simone;Vidler, Lewis R.;Breen, Gerome
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