Pharyngeal compliance in snoring subjects with and without obstructive sleep apnea.
Pharyngeal compliance in snoring subjects with and without obstructive sleep apnea.
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有或没有阻塞性睡眠呼吸暂停的打鼾受试者的咽部顺应性。
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
V. Hoffstein
中科院分区：
文献类型：
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作者：
I. G. Brown;T. Bradley;E. Phillipson;N. Zamel;V. Hoffstein
最近的研究表明，阻塞性睡眠呼吸暂停患者的咽横截面积和上呼吸道肌张力降低。这些发现表明，即使在清醒状态下，这些患者的咽部也可能比正常人更顺从。我们通过检查13名患者和7名对照受试者的咽压力-面积关系来验证这一假设。测量是在清醒状态下进行的，受试者坐着，肺容量恒定，接近功能残余容量。采用声反射法测量咽面积。咽压的变化是通过让受试者对远端闭塞的气道进行逐渐的吸气和呼气等容积操作来实现的，同时记录口腔压力。咽的特定顺应性计算为在0和-10 cm H2O之间以及0和10 cm H2O之间咽面积的分数变化。对照组和OSA患者的特异性咽部顺应性分别为0.036 +/- 0.004 cm H2O-1（平均+/- SE）和0.094 +/- 0.012 cm H2O-1 （p < 0.01）。这些发现表明阻塞性睡眠呼吸暂停患者的咽顺应性增加。当咽壁负压力在睡眠中产生时，这种异常易导致咽闭塞。
Recent studies have demonstrated a reduction in pharyngeal cross-sectional area and in upper airway muscle tone in patients with obstructive sleep apnea. These findings suggest that the pharynx in such patients may be more compliant than normal even in the awake state. We have tested this hypothesis by examining the pressure-area relationship of the pharynx in 13 patients and in 7 control subjects. Measurements were performed during wakefulness, with the subject seated, and at a constant lung volume near functional residual capacity. Pharyngeal area was measured by an acoustic reflection technique. Pharyngeal pressure was varied by having the subject perform gradual inspiratory and expiratory isovolume maneuvers against a distally occluded airway while mouth pressure was recorded. Specific compliance of the pharynx was calculated as the fractional change in pharyngeal area between a pressure of 0 and -10 cm H2O and and between 0 and 10 cm H2O. Specific pharyngeal compliance was 0.036 +/- 0.004 cm H2O-1 (mean +/- SE) in the control group and 0.094 +/- 0.012 cm H2O-1 in patients with OSA (p less than 0.01). These findings indicate that patients with obstructive sleep apnea have increased pharyngeal compliance. This abnormality predisposes to pharyngeal occlusion during sleep when negative transmural pressures are generated in the pharynx.
在患有睡眠呼吸暂停的清醒患者中用负压诱导气道塌陷。
DOI：
10.1152/jappl.1984.57.1.140
发表时间：
1984
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
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作者：
Suratt,PM;Wilhoit,SC;Cooper,K
通讯作者：
Cooper,K