Molecular evolution of eastern equine encephalomyelitis virus in North America.
Molecular evolution of eastern equine encephalomyelitis virus in North America.
复制标题
北美东部马脑脊髓炎病毒的分子进化。
DOI：
10.1016/0042-6822(91)90618-l
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发表时间：
1991
期刊：
影响因子：
3.7
通讯作者：
Rico-Hesse,R
中科院分区：
文献类型：
--
作者：
Weaver,SC;Scott,TW;Rico-Hesse,R
We examined the rate and spatial pattern of eastern equine encephalomyelitis virus (EEEV) evolution in North America using primer-extension sequencing of viral RNA. Nucleotide sequences of the entire 26 S structural gene region of four EEEV strains revealed remarkable conservation between 1933 and 1985, with an estimated 0.7% divergence or 1.4 × 10−4nucleotide substitutions per site per year. Sequences from smaller 26 S regions of nine additional strains suggested that EEEV evolves in North America in a single lineage, with genetic exchange regularly occurring among enzootic transmission foci. In these limited 26 S genome regions, only synonymous nucleotide substitutions became fixed between 1933 and 1988, implying a high degree of conservation in protein structure. Short nucleotide sequences from a Panamanian, South American variety isolate revealed a relatively distant relationship to North American serotype viruses. This suggested genetic divergence between antigenic varieties, and independent evolution of EEEV in North and South America. Factors related to replication and epidemiology of EEEV, which may constrain its evolution in nature, are discussed. Possible mechanisms of genetic exchange among enzootic foci are also considered.
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影响因子：
5
作者：
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通讯作者：
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影响因子：
3.7
作者：
Durbin,RK;Stollar,V
通讯作者：
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影响因子：
--
作者：
J. Holland
通讯作者：
J. Holland
东部马脑脊髓炎病毒与定植的 Culiseta melanura (Coquillett) 的感染和传播。
影响因子：
3.3
作者：
J. J. Howard;R. C. Wallis
通讯作者：
R. C. Wallis
对媒介蚊子库蚊 (Melanoconion) taeniopus 中委内瑞拉马脑脊髓炎病毒感染模式的电子显微镜分析。
影响因子：
3.3
作者：
S. Weaver
通讯作者：
S. Weaver