Induction of luteal regression in the marmoset monkey (Callithrix jacchus) by a gonadotrophin-releasing hormone antagonist and the effects on subsequent follicular development.
Induction of luteal regression in the marmoset monkey (Callithrix jacchus) by a gonadotrophin-releasing hormone antagonist and the effects on subsequent follicular development.
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促性腺激素释放激素拮抗剂诱导狨猴（Callithrix jacchus）黄体退化及其对随后卵泡发育的影响。
DOI：
10.1530/jrf.0.0820743
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
S. Lightman
中科院分区：
文献类型：
--
作者：
J. Hodges;D. I. Green;P. Cottingham;M. Sauer;C. Edwards;S. Lightman
新的促性腺激素释放激素拮抗剂[N-乙酰-Dβ-Na11-D-pCl-Phe2-D-Phe3-D-Arg6-Phe7-Arg8-D-Ala10]NH2促性腺激素释放激素](4只/只)在黄体期第10/11天给予100或200微克(4只/剂量)，在治疗1d内显著抑制循环中生物活性的促黄体生成素和孕酮浓度(P<0.01)。此后，孕酮浓度一直很低或检测不到，直到下一次排卵。在黄体期的第5/6天(N=4)给予200微克的拮抗剂也得到了类似的结果。注射拮抗剂(200微克而不是100微克)至排卵(孕酮升高至10 ng/ml以上)的间隔时间(P<0.01)明显长于对照周期中前列腺素诱导的黄体退化至排卵(N=4个/治疗周期)(拮抗剂后13~15天与前列腺素8~10天，P<0.01)。这4-5天的延迟相当于去卵巢动物(N=3)给予200微克拮抗剂后显著抑制黄体生成素浓度的持续时间。促性腺激素释放激素拮抗剂治疗后黄体功能恢复正常。这些结果表明，绒猴黄体功能和排卵前卵泡的发育依赖于垂体促性腺激素的分泌。
Doses of 100 or 200 micrograms of a novel GnRH antagonist ([N-acetyl-D beta Na11-D-pCl-Phe2-D-Phe3-D-Arg6-Phe7-Arg8-D-Ala10]NH2 GnRH) (4 animals/dose) were administered on Days 10/11 of the luteal phase and induced a marked suppression of circulating bioactive LH and progesterone concentrations within 1 day of treatment (P less than 0.01). Thereafter, progesterone concentrations remained low or undetectable until after the next ovulation. Similar results were obtained when 200 micrograms antagonist were given on Days 5/6 of the luteal phase (N = 4). The interval from injection of antagonist (200 micrograms but not 100 micrograms) to ovulation (based on a rise in progesterone above 10 ng/ml) was significantly longer than that from prostaglandin-induced luteal regression to ovulation in control cycles (N = 4/treatment) (range, 13-15 days after antagonist vs 8-10 days after prostaglandin, P less than 0.01). This delay of 4-5 days was equivalent to the duration for which LH concentrations were significantly suppressed by 200 micrograms antagonist when administered to ovariectomized animals (N = 3). Corpus luteum function during the cycle after GnRH antagonist treatment appeared normal according to the pattern of circulating progesterone. These results show that corpus luteum function and preovulatory follicular development in the marmoset monkey are dependent on pituitary gonadotrophin secretion.
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使用促性腺激素释放激素拮抗剂作为探针，研究骑车女性的卵泡发生和黄体功能对脉动促性腺激素分泌的依赖性。
DOI：
10.1210/jcem-62-6-1250
发表时间：
1986
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Mais,V;Kazer,RR;Cetel,NS;Rivier,J;Vale,W;Yen,SS
通讯作者：
Yen,SS
LH-RH 拮抗剂 ([N-Ac-D-Trp(1)(3), D-p-Cl-Phe(2), D-Phe(6), D-Ala(10)]-LH- 的作用
影响因子：
2.9
作者：
Balmaceda,JP;Schally,AV;Coy,D;Asch,RH
通讯作者：
Asch,RH
恒河猴黄体在整个月经周期的黄体期依赖于垂体促性腺激素的分泌。
影响因子：
4.8
作者：
Hutchison,JS;Zeleznik,AJ
通讯作者：
Zeleznik,AJ
黄体生成素释放因子激动剂引起的黄体期缺陷：生育控制模型。
DOI：
10.1126/science.6797068
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sheehan,KL;Casper,RF;Yen,SS
通讯作者：
Yen,SS