Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans.
Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans.
复制标题
秀丽隐杆线虫盐趋化过程中环境的分子编码和突触解码。
DOI：
10.1038/s41467-022-30279-7
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发表时间：
2022-05-27
影响因子：
16.6
通讯作者：
Iino Y
中科院分区：
文献类型：
--
作者：
Hiroki S;Yoshitane H;Mitsui H;Sato H;Umatani C;Kanda S;Fukada Y;Iino Y
动物使用各种环境线索导航到有利的位置。然而，如何对目标信息进行编码和解码以产生朝向适当方向的迁移的机制尚未阐明。在这里，我们描述了向学习的NaCl浓度在秀丽隐杆线虫迁移的机制。在盐敏感神经元ASER中，经历的和当前感知的NaCl浓度之间的差异通过蛋白激酶C（PKC-1）信号传导途径编码为β-64/突触融合蛋白1A的Ser 65处的磷酸化。磷酸化影响来自ASER的基础谷氨酸传递，诱导重定向起始神经元的突触后反应的逆转（即，从抑制性到兴奋性），引导动物达到所经历的浓度。这一过程，即语境的解码，是通过突触后兴奋性和抑制性受体的不同敏感性来实现的。我们的研究结果揭示了基于突触可塑性的迁移机制，在概念上不同于经典的。线虫C.优雅线虫四处移动寻找最佳环境。这项工作演示了它如何使用盐感神经元ASER检测并向先前学习的盐度移动。
Animals navigate toward favorable locations using various environmental cues. However, the mechanism of how the goal information is encoded and decoded to generate migration toward the appropriate direction has not been clarified. Here, we describe the mechanism of migration towards a learned concentration of NaCl in Caenorhabditis elegans. In the salt-sensing neuron ASER, the difference between the experienced and currently perceived NaCl concentration is encoded as phosphorylation at Ser65 of UNC-64/Syntaxin 1 A through the protein kinase C(PKC-1) signaling pathway. The phosphorylation affects basal glutamate transmission from ASER, inducing the reversal of the postsynaptic response of reorientation-initiating neurons (i.e., from inhibitory to excitatory), guiding the animals toward the experienced concentration. This process, the decoding of the context, is achieved through the differential sensitivity of postsynaptic excitatory and inhibitory receptors. Our results reveal the mechanism of migration based on the synaptic plasticity that conceptually differs from the classical ones. The nematode C. elegans moves around to find an optimal environment. This work demonstrates how it can detect and move towards a previously learned salinity using the salt-sensing neuron ASER.
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影响因子：
14.9
作者：
Takayama J;Faumont S;Kunitomo H;Lockery SR;Iino Y
通讯作者：
Iino Y
影响因子：
16.6
作者：
Lindsay, Theodore H.;Thiele, Tod R.;Lockery, Shawn R.
通讯作者：
Lockery, Shawn R.
影响因子：
2
作者：
Calkins, Hugh;Hindricks, Gerhard;Yamane, Teiichi
通讯作者：
Yamane, Teiichi
秀丽隐杆线虫的双向趋热性是由 AFD 热感觉神经元驱动的不同感觉运动策略介导的
DOI：
10.1073/pnas.1315205111
发表时间：
2014-02-18
影响因子：
11.1
作者：
Luo, Linjiao;Cook, Nathan;Samuel, Aravinthan D. T.
通讯作者：
Samuel, Aravinthan D. T.
影响因子：
3.3
作者：
Dokshin GA;Ghanta KS;Piscopo KM;Mello CC
通讯作者：
Mello CC