The effects of obesity on skeletal muscle regeneration.
The effects of obesity on skeletal muscle regeneration.
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DOI：
10.3389/fphys.2013.00371
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发表时间：
2013-12-17
影响因子：
4
通讯作者：
Berdeaux R
中科院分区：
文献类型：
--
作者：
Akhmedov D;Berdeaux R
肥胖和代谢紊乱，如2型糖尿病，伴随着脂肪和非脂肪组织中脂肪沉积的增加，包括肝脏、胰腺、心脏和骨骼肌。最近的文献报道了肥胖小鼠骨骼肌损伤后的再生能力受损。虽然肥胖症和2型糖尿病患者的肌肉再生尚未被彻底研究，导致肥胖症患者肌肉再生减少的机制仍不清楚，但初步的发现表明，在脂质过载的情况下，肌肉卫星细胞的功能可能会受到损害。肥胖动物体内毒性脂质代谢产物增加、促炎细胞因子增加以及胰岛素和瘦素抵抗可能导致骨骼肌再生能力下降。此外，与肥胖相关的骨骼肌纤维和卫星细胞代谢状态的改变可能直接损害卫星细胞介导的修复潜力。在这里，我们讨论最近的研究，这些研究扩大了我们对肥胖如何负面影响骨骼肌维持和再生的理解。
Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by increased lipid deposition in adipose and non-adipose tissues including liver, pancreas, heart and skeletal muscle. Recent publications report impaired regenerative capacity of skeletal muscle following injury in obese mice. Although muscle regeneration has not been thoroughly studied in obese and type 2 diabetic humans and mechanisms leading to decreased muscle regeneration in obesity remain elusive, the initial findings point to the possibility that muscle satellite cell function is compromised under conditions of lipid overload. Elevated toxic lipid metabolites and increased pro-inflammatory cytokines as well as insulin and leptin resistance that occur in obese animals may contribute to decreased regenerative capacity of skeletal muscle. In addition, obesity-associated alterations in the metabolic state of skeletal muscle fibers and satellite cells may directly impair the potential for satellite cell-mediated repair. Here we discuss recent studies that expand our understanding of how obesity negatively impacts skeletal muscle maintenance and regeneration.
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