Identification and physicochemical characterization of 4-fluorobutyrfentanyl (1-((4-fluorophenyl)(1-phenethylpiperidin-4-yl)amino)butan-1-one, 4-FBF) in seized materials and post-mortem biological samples.
Identification and physicochemical characterization of 4-fluorobutyrfentanyl (1-((4-fluorophenyl)(1-phenethylpiperidin-4-yl)amino)butan-1-one, 4-FBF) in seized materials and post-mortem biological samples.
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检获材料和死后生物样品中 4-氟丁芬太尼（1-（（4-氟苯基）（1-苯乙基哌啶-4-基）氨基）丁-1-酮，4-FBF）的鉴定和理化特征。
DOI：
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发表时间：
2017
影响因子：
2.9
通讯作者：
M. Sajewicz
中科院分区：
文献类型：
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作者：
Marcin Rojkiewicz;M. Majchrzak;R. Celiński;P. Kuś;M. Sajewicz
在过去十年中，新的精神活性物质有了大幅增长。在这一组中，一个增长相当快的亚组是阿片类药物，它们基于芬太尼结构的修饰。在这项研究中，一个新的芬太尼衍生物，4-氟丁基芬太尼（1-（（4-氟苯基）（1-苯乙基哌啶-4-基）氨基）丁-1-酮，4-FBF）的鉴定和分析表征。除了检获的粉末外，在个案1的电子烟液体中亦发现4-FBF。该化合物在液体中的浓度为35 mg/mL。液体的主要成分是甘油，并且还存在尼古丁。在来自波兰非法毒品市场的缉获材料中检测到这种物质。据作者所知，本报告介绍了前两例经分析证实的与4-FBF相关的致命中毒病例。病例1为一名26岁男性吸毒者，被发现死于家中。病例2为一名25岁女性，偶尔使用海洛因和毒品，也被发现死于家中。血液中4-FBF的浓度为91和112 ng/mL，尿液中为200和414 ng/mL。病例1和病例2的肝脏和肾脏中的4-FBF浓度分别为902和411 ng/g以及136和197 ng/g。版权所有© 2016约翰威利父子有限公司.
During the last decade, a substantial growth in new psychoactive substances (NPS) has been recorded. Within this group, a considerably fast-growing sub-group is represented by the opioids, which are based on modifications of the fentanyl structure. In this study, identification and analytical characterization of a new fentanyl derivative, 4-fluorobutyrfentanyl (1-((4-fluorophenyl)(1-phenethylpiperidin-4-yl)amino)butan-1-one, 4-FBF), is described. Apart from the seized powder, 4-FBF was also identified in the e-cigarette liquid secured in Case 1. The concentration of the compound in the liquid was 35 mg/mL. The main component of the liquid was glycerol, and nicotine was also present. This substance was detected in seized material that originated from the illegal drug market in Poland. To the best of the authors' knowledge, this report presents the first two analytically confirmed cases of fatal intoxication associated with 4-FBF. Case 1 was a 26-year-old male drug user who was found dead at home. Case 2 was a 25-year-old female, occasional user of NPS and drugs, who was also found dead at home. The concentrations of 4-FBF in blood were 91 and 112 ng/mL and in urine 200 and 414 ng/mL. The concentrations of 4-FBF in liver and kidney were 902 and 411 ng/g, and 136 and 197 ng/g, for Case 1 and Case 2, respectively. Copyright © 2016 John Wiley & Sons, Ltd.
影响因子：
4.2
作者：
Vardanyan RS;Hruby VJ
通讯作者：
Hruby VJ