Stem and progenitor cells for neurological repair: minor issues, major hurdles, and exciting opportunities for paracrine-based therapeutics.
Stem and progenitor cells for neurological repair: minor issues, major hurdles, and exciting opportunities for paracrine-based therapeutics.
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DOI：
10.1002/jcb.22963
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发表时间：
2011-02
影响因子：
4
通讯作者：
Spees, Jeffrey L.
中科院分区：
文献类型：
--
作者：
Shimada, Issei S.;Spees, Jeffrey L.
培养的干细胞和祖细胞的移植是快速发展的再生医学领域的关键要素。基于其拯救和/或修复受损组织和部分恢复器官功能的能力，多种类型的干/祖细胞已经进入临床试验。然而，尽管进行了几十年的深入研究，但以能够有效替代损伤后细胞的方式应用培养扩增的干/祖细胞的目标尚未实现。许多潜在有用的细胞来源是可用的，但有些东西显然是缺失的。此外，最近的研究表明，分泌或释放的因子的旁分泌效应是细胞移植后观察到的大多数益处的原因，而不是直接的细胞替代。这些数据对细胞移植用于许多类型的治疗，特别是用于急性损伤如心肌梗死和中风的需要提出了质疑。在这篇综述中，我们研究了细胞移植领域的最新进展，以及不同细胞类型临床应用中的小问题和主要障碍。我们讨论了“旁分泌假说”的行动移植的干/祖细胞作为一个机会，以确定定义的组合的生物分子，以拯救和/或修复组织损伤后。虽然本综述中的许多概念将适用于多种损伤/修复系统，但我们将主要关注基于干/祖细胞的神经系统疾病和中风治疗。
The transplantation of cultured stem and progenitor cells is a key element in the rapidly growing field of regenerative medicine. Based on their ability to rescue and/or repair injured tissue and partially restore organ function, multiple types of stem/progenitor cells have already entered into clinical trials. However, despite several decades of intense research, the goal to apply culture-expanded stem/progenitor cells in a manner that can effectively replace cells after injury has yet to be realized. Many sources of potentially useful cells are available, but something is clearly missing. In addition, recent studies suggest that paracrine effects of secreted or released factors are responsible for most of the benefits observed after cell transplantation, rather than direct cell replacement. These data call into question the need for cell transplantation for many types of therapy, in particular for acute injuries such as myocardial infarction and stroke. In this review, we examine current progress in the area of cell transplantation and minor issues and major hurdles regarding the clinical application of different cell types. We discuss the “paracrine hypothesis” for the action of transplanted stem/progenitor cells as an opportunity to identify defined combinations of biomolecules to rescue and/or repair tissues after injury. Although many of the concepts in this review will apply to multiple injury/repair systems, we will focus primarily on stem/progenitor cell-based treatments for neurological disorders and stroke.
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影响因子：
4.8
作者：
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影响因子：
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影响因子：
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