Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons.
Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons.
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DOI：
10.1002/ana.26189
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发表时间：
2021-10
影响因子：
11.2
通讯作者：
Irani SR
中科院分区：
文献类型：
--
作者：
Ramanathan S;Tseng M;Davies AJ;Uy CE;Paneva S;Mgbachi VC;Michael S;Varley JA;Binks S;Themistocleous AC;Fehmi J;Anziska Y;Soni A;Hofer M;Waters P;Brilot F;Dale RC;Dawes J;Rinaldi S;Bennett DL;Irani SR
疼痛是富含亮氨酸的胶质瘤失活1（LGI 1）和接触蛋白相关蛋白样2（CASPR 2）抗体的一种未被充分认识的相关性。在147例具有这些自身抗体的患者中，33例CASPR 2抗体患者中有17例（52%）经历了疼痛，而108例LGI 1抗体患者中有20例（19%）经历了疼痛（p = 0.0005），其中分别有89%和58%被确定为神经性疼痛。通常，在两个队列中，在采样的患者亚组中观察到正常的神经传导研究和减少的表皮内神经纤维密度。在LGI 1抗体患者中，疼痛对免疫治疗有反应（p = 0.008），通常很快，在CASPR 2抗体患者中观察到更大的残留患者评定损害（p = 0.019）。血清CASPR 2抗体，而不是LGI 1抗体，在体外结合无髓鞘的人类感觉神经元和啮齿动物背根神经节，提示病理生理差异，可能是我们的临床观察的基础。神经网络2021;90：683-690
Pain is a under‐recognized association of leucine‐rich glioma‐inactivated 1 (LGI1) and contactin‐associated protein‐like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by 17 of 33 (52%) with CASPR2‐ versus 20 of 108 (19%) with LGI1 antibodies (p = 0.0005), and identified as neuropathic in 89% versus 58% of these, respectively. Typically, in both cohorts, normal nerve conduction studies and reduced intraepidermal nerve fiber densities were observed in the sampled patient subsets. In LGI1 antibody patients, pain responded to immunotherapy (p = 0.008), often rapidly, with greater residual patient‐rated impairment observed in CASPR2 antibody patients (p = 0.019). Serum CASPR2 antibodies, but not LGI1 antibodies, bound in vitro to unmyelinated human sensory neurons and rodent dorsal root ganglia, suggesting pathophysiological differences that may underlie our clinical observations. ANN NEUROL 2021;90:683–690
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影响因子：
16.2
作者：
Dawes JM;Weir GA;Middleton SJ;Patel R;Chisholm KI;Pettingill P;Peck LJ;Sheridan J;Shakir A;Jacobson L;Gutierrez-Mecinas M;Galino J;Walcher J;Kühnemund J;Kuehn H;Sanna MD;Lang B;Clark AJ;Themistocleous AC;Iwagaki N;West SJ;Werynska K;Carroll L;Trendafilova T;Menassa DA;Giannoccaro MP;Coutinho E;Cervellini I;Tewari D;Buckley C;Leite MI;Wildner H;Zeilhofer HU;Peles E;Todd AJ;McMahon SB;Dickenson AH;Lewin GR;Vincent A;Bennett DL
通讯作者：
Bennett DL
影响因子：
64.5
作者：
Zeisel, Amit;Hochgerner, Hannah;Linnarsson, Sten
通讯作者：
Linnarsson, Sten
影响因子：
11.2
作者：
Irani, Sarosh R.;Michell, Andrew W.;Vincent, Angela
通讯作者：
Vincent, Angela
DOI：
10.1093/brain/awx012
发表时间：
2017-04-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Clark AJ;Kaller MS;Galino J;Willison HJ;Rinaldi S;Bennett DLH
通讯作者：
Bennett DLH
影响因子：
5.1
作者：
Lauria, G.;Hsieh, S. T.;Valls-Sole, J.
通讯作者：
Valls-Sole, J.