MoYvh1 subverts rice defense through functions of ribosomal protein MoMrt4 in Magnaporthe oryzae.
MoYvh1 subverts rice defense through functions of ribosomal protein MoMrt4 in Magnaporthe oryzae.
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MoYvh1 通过核糖体蛋白 MoMrt4 的功能破坏稻瘟病菌的防御
DOI：
10.1371/journal.ppat.1007016
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发表时间：
2018-04
期刊：
影响因子：
6.7
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Liu X;Yang J;Qian B;Cai Y;Zou X;Zhang H;Zheng X;Wang P;Zhang Z
水稻体内活性氧（ROS）的积累在其与稻瘟病菌（Magnaporthe）的相互作用中起重要作用，在此过程中病菌通过产生促进稻瘟病的胞外酶来清除ROS。我们以前的特点MoYvh 1蛋白磷酸酶从M。在清除ROS中起作用的酶。为了了解潜在的机制，我们发现MoYvh1在氧化应激后易位到细胞核中，并且这种易位依赖于与热休克蛋白70（Hsp70）蛋白同源的MoSsb1和MoSsz1。此外，我们建立了MoYvh1和MoMrt4之间的联系，MoMrt4是一种核糖体成熟因子同源物，其功能也涉及在细胞质和细胞核之间穿梭。此外，我们发现MoYvh1调节调节水稻免疫的胞外蛋白的产生。综上所述，我们的证据表明，MoYvh1在调节ROS清除功能需要其核质穿梭和伴侣蛋白MoSsb1和MoSsz1，以及MoMrt4。我们的研究结果提供了新的见解的机制，M。它通过调节核糖体的生物合成和蛋白质的生物合成来响应和破坏宿主免疫。
The accumulation of the reactive oxygen species (ROS) in rice is important in its interaction with the rice blast fungus Magnaporthe oryzae during which the pathogen scavenges ROS through the production of extracellular enzymes that promote blast. We previously characterized the MoYvh1 protein phosphatase from M. oryzae that plays a role in scavenging of ROS. To understand the underlying mechanism, we found that MoYvh1 is translocated into the nucleus following oxidative stress and that this translocation is dependent on MoSsb1 and MoSsz1 that are homologous to heat-shock protein 70 (Hsp70) proteins. In addition, we established a link between MoYvh1 and MoMrt4, a ribosome maturation factor homolog whose function also involves shuttling between the cytoplasm and the nucleus. Moreover, we found that MoYvh1 regulates the production of extracellular proteins that modulate rice-immunity. Taking together, our evidence suggests that functions of MoYvh1 in regulating ROS scavenging require its nucleocytoplasmic shuttling and the partner proteins MoSsb1 and MoSsz1, as well as MoMrt4. Our findings provide novel insights into the mechanism by which M. oryzae responds to and subverts host immunity through the regulation of ribosome biogenesis and protein biosynthesis.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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DOI：
10.1083/jcb.200904111
发表时间：
2009-09-21
期刊：
The Journal of cell biology
影响因子：
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DOI：
10.1016/j.bbagen.2005.03.009
发表时间：
2005-06-20
影响因子：
3
作者：
Krokowski, D;Tchórzewski, M;Grankowski, N
通讯作者：
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