Role of Streptococcus mutans surface proteins for biofilm formation.
Role of Streptococcus mutans surface proteins for biofilm formation.
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DOI：
10.1016/j.jdsr.2017.08.002
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Matsumoto-Nakano M
中科院分区：
文献类型：
--
作者：
Matsumoto-Nakano M
变形链球菌是人类龋齿的主要致病因子。这种细菌的一个重要毒性特性是它能够在牙齿表面形成被称为牙菌斑的生物膜。此外，该生物体还产生葡糖基转移酶、多种葡聚糖结合蛋白、蛋白抗原c和胶原结合蛋白，这些表面蛋白协同产生牙菌斑，从而诱导龋齿。细菌利用群体感应系统调节环境应激反应。信号应答的一个主要机制是所谓的双组分信号转导系统，该系统使细菌能够调节其基因表达并协调活动以响应环境胁迫。至于S.已经发现，由comCDE编码的信号肽介导的群体感应系统（quorum-sensing system）是通过分泌称为CSP（competence-stimulating peptide）的肽信号分子来响应细胞密度和某些环境应激的调节系统。其主要毒力因子之一是产生称为突变素的细菌素（肽抗生素）。双组分信号转导系统通常被细菌用来调节细菌素基因的表达，也与S.变种人
Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to modulate environmental stress responses. A major mechanism of response to signals is represented by the so called two-component signal transduction system, which enables bacteria to regulate their gene expression and coordinate activities in response to environmental stress. As for S. mutans, a signal peptide-mediated quorum-sensing system encoded by comCDE has been found to be a regulatory system that responds to cell density and certain environmental stresses by excreting a peptide signal molecule termed CSP (competence-stimulating peptide). One of its principal virulence factors is production of bacteriocins (peptide antibiotics) referred to as mutacins. Two-component signal transduction systems are commonly utilized by bacteria to regulate bacteriocin gene expression and are also related to biofilm formation by S. mutans.
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影响因子：
3.1
作者：
HANADA, N;KURAMITSU, HK
通讯作者：
KURAMITSU, HK
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3.1
作者：
Idone, V;Brendtro, S;Spatafora, G
通讯作者：
Spatafora, G
影响因子：
15.9
作者：
Cvitkovitch, DG;Liu, YH;Ellen, RP
通讯作者：
Ellen, RP
影响因子：
3.2
作者：
Biswas, S;Biswas, I
通讯作者：
Biswas, I
影响因子：
3.8
作者：
DEMUTH, DR;LAMMEY, MS;MALAMUD, D
通讯作者：
MALAMUD, D