Ion channels, ion channel receptors, and visceral hypersensitivity in irritable bowel syndrome.
Ion channels, ion channel receptors, and visceral hypersensitivity in irritable bowel syndrome.
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DOI：
10.1111/nmo.12979
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发表时间：
2016-11
影响因子：
3.5
通讯作者：
Christianson JA
中科院分区：
文献类型：
--
作者：
Fuentes IM;Christianson JA
离子通道在整个胃肠道系统中表达，几乎调节消化的方方面面，包括液体的分泌和吸收、运动和内脏敏感性。因此，在肠易激综合征(IBS)等功能性肠道疾病的背景下，离子通道的表达水平和功能经常发生变化，并成为药物干预的目标，这一点也就不足为奇了。尤其是它们通过内脏高敏感性(VH)驱动腹痛，这是IBS患者寻求医疗服务的主要原因。在Scanzi等人的研究中，他们在最新一期的杂志上提供了证据，证明T型电压门控钙通道(Cav)Cav3.2在人类IBS患者中上调，并且对于诱导小鼠的IBS样疾病状态是必要的。在这篇简短的综述中，我们将讨论在IBS患者和啮齿动物模型中，特定的离子通道对VH的贡献。我们还将讨论Cav3.2如何作为促成VH的多个环境刺激的集成者发挥作用。离子通道在整个胃肠道系统中表达，几乎调节消化的方方面面，包括液体的分泌和吸收、运动和内脏敏感性。在这篇简短的综述中，我们将讨论在人类患者和啮齿动物模型中，特定的离子通道和离子通道受体在肠易激综合征内脏高敏感性中的作用。
Ion channels are expressed throughout the gastrointestinal system and regulate nearly every aspect of digestion, including fluid secretion and absorption, motility, and visceral sensitivity. It is therefore not surprising that in the setting of functional bowel disorders, such as irritable bowel syndrome (IBS), ion channels are often altered in terms of expression level and function and are a target of pharmacological intervention. This is particularly true of their role in driving abdominal pain through visceral hypersensitivity (VH), which is the main reason IBS patients seek medical care. In the study by Scanzi et al., in the current issue of this journal, they provide evidence that the T-type voltage-gated calcium channel (Cav) Cav3.2 is upregulated in human IBS patients, and is necessary for the induction of an IBS-like disease state in mice. In this mini-review, we will discuss the contribution of specific ion channels to VH in IBS, both in human patients and rodent models. We will also discuss how Cav3.2 may play a role as an integrator of multiple environmental stimuli contributing towards VH. Ion channels are expressed throughout the gastrointestinal system and regulate nearly every aspect of digestion, including fluid secretion and absorption, motility, and visceral sensitivity. In this mini-review, we will discuss the contribution of specific ion channels and ion channel receptors to visceral hypersensitivity in irritable bowel syndrome, both in human patients and rodent models.
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影响因子：
29.4
作者：
Cenac, Nicolas;Bautzova, Tereza;Vergnolle, Nathalie
通讯作者：
Vergnolle, Nathalie
影响因子：
4
作者：
Cribbs, Leanne L.
通讯作者：
Cribbs, Leanne L.
影响因子：
7.6
作者：
Mayer, EA;Berman, S;Naliboff, BD
通讯作者：
Naliboff, BD
影响因子：
7.4
作者：
Christianson JA;Bielefeldt K;Malin SA;Davis BM
通讯作者：
Davis BM
DOI：
10.1152/ajpgi.00237.2016
发表时间：
2016-10-01
影响因子：
4.5
作者：
Beyder, Arthur;Farrugia, Gianrico
通讯作者：
Farrugia, Gianrico