Human herpesvirus 7 infection of lymphoid and myeloid cell lines transduced with an adenovirus vector containing the CD4 gene
Human herpesvirus 7 infection of lymphoid and myeloid cell lines transduced with an adenovirus vector containing the CD4 gene
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用含有 CD4 基因的腺病毒载体转导的人疱疹病毒 7 感染淋巴和骨髓细胞系
DOI：
10.1128/jvi.71.2.1708-1712.1997
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发表时间：
1997
影响因子：
5.4
通讯作者：
S. Fujita
中科院分区：
文献类型：
--
作者：
M. Yasukawa;Y. Inoue;H. Ohminami;E. Sada;K. Miyake;T. Tohyama;T. Shimada;S. Fujita
最近有报道，CD 4是人类疱疹病毒7型（HHV-7）受体的主要成分，HHV-7已被新鉴定为嗜T淋巴细胞病毒。为了进一步研究CD 4在HHV-7感染中的作用，我们检测了各种CD 4阴性或弱阳性细胞系对HHV-7感染的易感性，其中使用腺病毒载体（Adex 1CACD 4）将CD 4的cDNA转移到这些细胞系中。Adex 1CACD 4转导的13个细胞系中，包括T淋巴细胞系、B淋巴细胞系、单核细胞样细胞系和髓样细胞系，一个T淋巴细胞系、一个单核细胞样细胞系和两个从慢性髓性白血病急变建立的细胞系显示出对HHV-7感染的高易感性。与以前的研究结果一起，这些数据强烈表明，CD 4是HHV-7结合受体的主要成分。这项研究还表明，HHV-7可能能够感染CD 4阳性造血前体细胞以及T淋巴细胞。
It has been reported recently that CD4 is a major component of the receptor for human herpesvirus 7 (HHV-7), which has been newly identified as a T-lymphotropic virus. To investigate further the role of CD4 in HHV-7 infection, we examined the susceptibility to HHV-7 infection of various CD4-negative or weakly positive cell lines into which the cDNA for CD4 was transferred using an adenovirus vector (Adex1CACD4). Of 13 cell lines transduced with Adex1CACD4, including T-lymphoid, B-lymphoid, monocytoid, and myeloid cell lines, one T-lymphoid cell line, one monocytoid cell line, and two cell lines established from the blast crisis of chronic myelogenous leukemia showed high susceptibility to HHV-7 infection. Taken together with the results of previous studies, these data suggest strongly that CD4 is a major component of the binding receptor for HHV-7. This study also shows that HHV-7 may be able to infect CD4-positive hematopoietic precursor cells as well as T lymphocytes.
DOI：
10.1073/pnas.89.21.10552
发表时间：
1992-11-01
影响因子：
11.1
作者：
BERNEMAN, ZN;ABLASHI, DV;GALLO, RC
通讯作者：
GALLO, RC