Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.
Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.
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DOI：
10.1155/2010/263810
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发表时间：
2010
影响因子：
--
通讯作者：
Imawari M
中科院分区：
文献类型：
--
作者：
Hiroishi K;Eguchi J;Ishii S;Hiraide A;Sakaki M;Doi H;Omori R;Imawari M
细胞毒性T淋巴细胞（CTL）的免疫应答与丙型肝炎病毒的根除和发病机制有关。HCV感染会损害HCV特异性ctl的功能；HCV蛋白被认为积极抑制宿主免疫反应，包括ctl。在HCV感染患者中诱导强烈的HCV特异性CTL反应可以促进完全的HCV清除。因此，强烈期望开发一种疫苗，可以诱导有效的CTL反应对抗HCV。我们通过酶联免疫斑点试验和/或合成肽研究了HCV特异性CTL反应，并在HCV蛋白中鉴定了40多个新的CTL表位。我们的发现可能有助于HCV疫苗的开发。在本文中，我们描述了丙型肝炎病毒感染的CTL反应和疫苗开发的尝试。
Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.
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