Effects of unilateral hyperinflation on the interpulmonary distribution of pleural pressure.
Effects of unilateral hyperinflation on the interpulmonary distribution of pleural pressure.
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单侧过度充气对胸膜压力肺间分布的影响。
DOI：
10.1152/jappl.1992.73.4.1650
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Margulies,SS
中科院分区：
文献类型：
--
作者：
Hubmayr,RD;Margulies,SS
受单肺移植的启发，我们研究了卧式狗和狒狒在单肺充气过程中胸壁的力学结构，并确定了胸膜压力（Ppl）如何在半胸之间耦合。在一组实验中，Ppl 的分布是根据每个肺的已知体积和弹性特性推断的。在第二组实验中，用肋骨胶囊测量肋胸膜液体压力（Pplcos）。两种方法均显示同侧或充气肺的 Ppl 增加 (delta Ppli) 大于对侧或非充气肺的 Ppl 增加 (delta Pplc)。狗的平均 d(delta Pplc)/d(delta Ppli) 及其 95% 置信区间为 0.7 +/- 0.1，狒狒为 0.5 +/- 0.1。在三只狗和三只狒狒的第三组实验中，我们防止胸骨移位，并在单侧肺部充气期间将腹部隔膜暴露在大气压力下。这些干预措施对半胸之间的 Ppl 耦合没有显着影响。我们得出的结论是，大小和机械性能不同的肺不需要暴露于相同的表面压力，因为胸廓中线结构和肺本身可以抵抗位移和变形。
Motivated by single lung transplantation, we studied the mechanics of the chest wall during single lung inflations in recumbent dogs and baboons and determined how pleural pressure (Ppl) is coupled between the hemithoraces. In one set of experiments, the distribution of Ppl was inferred from known volumes and elastic properties of each lung. In a second set of experiments, costal pleural liquid pressure (Pplcos) was measured with rib capsules. Both methods revealed that the increase in Ppl over the ipsilateral or inflated lung (delta Ppli) is greater than that over the contralateral or noninflated lung (delta Pplc). Mean d(delta Pplc)/d(delta Ppli) and its 95% confidence interval was 0.7 +/- 0.1 in dogs and 0.5 +/- 0.1 in baboons. In a third set of experiments in three dogs and three baboons, we prevented sternal displacement and exposed the abdominal diaphragm to atmospheric pressure during unilateral lung inflation. These interventions had no significant effect on Ppl coupling between the hemithoraces. We conclude that lungs of unequal size and mechanical properties need not be exposed to the same surface pressure, because thoracic midline structures and the lungs themselves resist displacement and deformation.
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使用肋骨囊测量狗的胸膜液压力。
DOI：
10.1152/jappl.1985.59.2.597
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Wiener-Kronish,JP;Gropper,MA;Lai-Fook,SJ
通讯作者：
Lai-Fook,SJ
影响因子：
3.3
作者：
LAIFOOK, SJ;WILSON, TA;RODARTE, JR
通讯作者：
RODARTE, JR
DOI：
--
发表时间：
2015
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
A. Baydur;P. Behrakis;W. Zin;M. Jaeger;J. Milic‐Emili
通讯作者：
J. Milic‐Emili
影响因子：
3.3
作者：
D. Gillespie;Y. Lai;R. Hyatt
通讯作者：
R. Hyatt
实验性肺气肿和人类肺气肿的单肺移植
影响因子：
9
作者：
Frank Veith;S. Koerner;Stanley S. Siegeman;M. Torres;P. Bardfeld;L. Attai;S. Boley;T. Takaro;Marvin L. Cliedman
通讯作者：
Marvin L. Cliedman