S100P expression in response to sex steroids during the implantation window in human endometrium.
S100P expression in response to sex steroids during the implantation window in human endometrium.
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DOI：
10.1186/1477-7827-10-106
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发表时间：
2012-12-07
期刊：
影响因子：
--
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Zhang D;Ma C;Sun X;Xia H;Zhang W
S100P是一种最初在人类胎盘中检测到的蛋白质，现已发现在肿瘤的发展和侵袭中发挥重要作用。有趣的是，我们最近使用数据挖掘发现，S100P 在人类子宫内膜着床期间显着上调，但目前还没有进一步的信息。采用实时荧光定量PCR和免疫荧光检测S100P在人子宫内膜和子宫内膜细胞中的表达和定位。将雌激素和黄体酮添加到培养的细胞中以测试S100P对性类固醇的反应。在分泌中期（对应于胚胎植入时间）的子宫内膜中观察到了一个戏剧性的峰值，与增殖期和早期分泌期和晚期分泌期相比增加了大约 100 倍。孕激素调节原代子宫内膜上皮细胞和基质细胞中S100P的表达，但雌激素没有显着影响。研究结果表明，S100P在孕激素的调控下参与子宫内膜的周期性变化，可能作为容受性子宫内膜的独特生物标志物，在胚胎着床中发挥重要作用。
S100P, a protein originally detected in the human placenta, has been found to play an important role in the development and invasion of tumors. Interestingly, we have recently discovered using data mining that S100P was considerably up-regulated during the window of implantation in the human endometrium, but little further information has been available. Real-time PCR and immunofluorescence were performed to examine the expression and location of S100P in the human endometrium and endometrial cells. Estrogen and progesterone were added to the cultured cells to test the response of S100P to sex steroids. A dramatic peak, approximately a 100-fold increase in comparison with the proliferative and early- and late-secretory phases, was observed in the endometrium during the mid-secretory phase, which corresponds to the time of embryo implantation. Progesterone regulated the expression of S100P in both primary endometrial epithelial and stromal cells, but estrogen had no significant effect. The results indicate that S100P participates in the periodic change of the endometrium under the regulation of progesterone, may be used as a unique biomarker of the receptive endometrium and play an important role in embryo implantation.
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