Polarized dendritic cells as cancer vaccines: directing effector-type T cells to tumors.
Polarized dendritic cells as cancer vaccines: directing effector-type T cells to tumors.
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DOI：
10.1016/j.smim.2010.03.002
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发表时间：
2010-06
影响因子：
7.8
通讯作者：
Okada H
中科院分区：
文献类型：
--
作者：
Kalinski P;Okada H
肿瘤患者树突状细胞(DC)的体外生成和抗原负载有助于绕过内源性DC的功能障碍。它还允许控制DC成熟的过程，并在成熟的DC中印记几种诱导有效形式的癌症免疫所必需的功能。最近包括我们在内的几个小组的报告表明，DC的产生和成熟的不同条件可以为DC与不同的(效应者和调节性)免疫细胞亚群的优先相互作用做准备。此外，差异产生的树突状细胞在CD4+和CD8+T细胞中印记不同的效应机制(传递“信号三”)，并诱导它们不同的归巢特性(传递“信号四”)。这些进展允许选择性地诱导具有理想效应功能和肿瘤相关归巢特性的肿瘤特异性T细胞，并将理想类型的免疫细胞定向到肿瘤。
Ex-vivo-generation and antigen loading of dendritic cells (DCs) from cancer patients helps to bypass the dysfunction of endogenous DCs. It also allows to control the process of DC maturation and to imprint in maturing DCs several functions essential for induction of effective forms of cancer immunity. Recent reports from several groups including ours demonstrate that distinct conditions of DC generation and maturation can prime DCs for preferential interaction with different (effector versus regulatory) subsets of immune cells. Moreover, differentially-generated DCs have been shown to imprint different effector mechanisms in CD4+ and CD8+ T cells (delivery of “signal three”) and to induce their different homing properties (delivery of “signal four”). These developments allow for selective induction of tumor-specific T cells with desirable effector functions and tumor-relevant homing properties and to direct the desirable types of immune cells to tumors.
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