Neural Systems Underlying Arousal and Attention: Implications for Drug Abuse a
Neural Systems Underlying Arousal and Attention: Implications for Drug Abuse a
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唤醒和注意力的神经系统：对药物滥用的影响
DOI：
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发表时间：
1998
影响因子：
5.2
通讯作者：
Barry J. Everitt
中科院分区：
文献类型：
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作者：
T. W. Robbins;S. Granon;Janice L. Muir;F. Durantou;A. A. Harrison;Barry J. Everitt
摘要：单胺和胆碱能系统与不同形式的行为觉醒有关，可以根据它们的前脑靶点和它们在不同区域调节的行为过程的性质来剖析。因此，在接受选择性神经化学操作的大鼠中，有证据表明，蓝斑皮质去甲肾上腺素系统参与分离和选择性注意，基底前脑胆碱能系统参与刺激检测，中纹状体和中脑边缘多巴胺系统参与反应速度和活力，中脑5-羟色胺或5-羟色胺系统参与反应抑制。我们最近的研究集中于在同一任务中，分离背侧和中缝中缝5-羟色胺系统的不同贡献，以及阐明中皮质多巴胺系统的功能，其中每一项都可能与理解可卡因给药在人类受试者和实验动物中的行为和认知后遗症有关。
ABSTRACT: The monoaminergic and cholinergic systems are implicated in different forms of behavioral arousal that can be dissected in terms of their forebrain targets and the nature of the behavioral processes they modulate in distinct regions. Thus, evidence in rats with selective neurochemical manipulations tested behaviorally using an analog of an attentional task developed for human subjects indicates that the coeruleo‐cortical noradrenergic system is implicated in divided and selective attention, the basal forebrain cholinergic system in stimulus detection, the mesostriatal and mesolimbic dopaminergic systems in response speed and vigor, and the mesencephalic serotoninergic or 5‐HT systems in response inhibition. Our recent studies have focused on fractionating, in the same task, the differential contributions of the dorsal and median raphé 5‐HT systems as well as elucidating the functions of the mesocortical dopaminergic system, each of which may be relevant to understanding the behavioral and cognitive sequelae of cocaine administration in human subjects as well as in experimental animals.
影响因子：
--
作者：
Gary Aston-Jones;C. Chiang;T. Alexinsky
通讯作者：
Gary Aston-Jones;C. Chiang;T. Alexinsky
影响因子：
56.9
作者：
GOEDERS, NE;SMITH, JE
通讯作者：
SMITH, JE
影响因子：
2.6
作者：
Barry Zuckerman;K. Bresnahan
通讯作者：
Barry Zuckerman;K. Bresnahan