Autologous albumin enhances the humoral immune response to capsular polysaccharide covalently coattached to bacteria-sized latex beads.
Autologous albumin enhances the humoral immune response to capsular polysaccharide covalently coattached to bacteria-sized latex beads.
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DOI：
10.1002/eji.201344266
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发表时间：
2014-05
影响因子：
5.4
通讯作者：
Snapper, Clifford M.
中科院分区：
文献类型：
--
作者：
Colino, Jesus;Duke, Leah;Snapper, Clifford M.
Abundant autologous proteins, like serum albumin, should be immunologically inert. However, individuals with no apparent predisposition to autoimmune disease can develop immune responses to autologous therapeutic proteins. Protein aggregation is a potential major trigger of these responses. Adsorption of proteins to particles provides macromolecular size and may generate structural changes in the protein, resembling aggregation. Using aldehyde/sulfate latex beads coated with murine serum albumin (MSA), we found that mice mounted MSA-specific IgG responses that were dependent on CD4+ T cells. IgG were specific for MSA adsorbed to solid surfaces and non-cross-reactive with human, bovine or pig albumins. T cells induced in response to MSA, augmented the primary and induced boosted secondary IgG and IgM responses specific for the T cell-independent antigen, capsular polysaccharide of Streptococcus pneumoniae type 14 (PPS14), when the latter was attached to the same bead. Similar to the anti-MSA IgG response, the boosted PPS14-specific IgG secondary response was CD4+ T cell-dependent, displayed a typical carrier effect, and was enhanced by, but did not require, Toll-like receptor stimulation. These results provide a potential mechanism for the induction of responses to autoantigens unable to induce specific T cell responses, and provide new insights into polysaccharide-specific immunity.
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影响因子：
4.8
作者：
Bouma, B;Kroon-Batenburg, LMJ;Gebbink, MFBG
通讯作者：
Gebbink, MFBG
影响因子：
3.1
作者：
Colino, Jesus;Snapper, Clifford M.
通讯作者：
Snapper, Clifford M.
Toll样受体9控制鼠狼疮中的抗DNA自身抗体产生。
DOI：
10.1084/jem.20050338
发表时间：
2005-07-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Christensen SR;Kashgarian M;Alexopoulou L;Flavell RA;Akira S;Shlomchik MJ
通讯作者：
Shlomchik MJ
DOI：
10.1016/s0074-7696(06)50005-1
发表时间：
2006
期刊：
International review of cytology
影响因子：
--
作者：
Kraal G;Mebius R
通讯作者：
Mebius R
影响因子：
4.4
作者：
Chackerian, Bryce;Durfee, Marisa R.;Schiller, John T.
通讯作者：
Schiller, John T.