Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.
Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.
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DOI：
10.1038/s41386-022-01312-6
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发表时间：
2022-08
影响因子：
7.6
通讯作者：
Walton, Mark E.
中科院分区：
文献类型：
--
作者：
Grima, Laura L.;Panayi, Marios C.;Harmson, Oliver;Syed, Emilie C. J.;Manohar, Sanjay G.;Husain, Masud;Walton, Mark E.
众所周知，多巴胺传递在调节奖赏期望对奖赏寻求行为的影响中是不可或缺的。然而，多巴胺传递在每时每刻的奖励动机行为控制中的确切因果作用仍然存在争议，特别是在需要避免做出反应以实现有益结果的情况下。为了验证这一点，我们操纵了多巴胺的传递神经元，让老鼠执行一个Go/No-Go任务，要求它们要么采取行动，要么不采取行动，以获得或大或小的奖励。D1 R刺激增强了线索驱动的动作启动，包括No-Go试验中的快速冲动动作。相比之下，D1 R阻断主要破坏Go试验序列的成功完成。令人惊讶的是，虽然在全球D1 R封锁后，这是由奖励寻求行动的一般延迟的特点，核脑桥核心（NAcC）D1 R封锁行动启动或冲动行动的速度没有影响。相反，细粒度的分析表明，这种操纵降低了动物目标导向行为的精确性，即使它们通常仍然遵循适当的反应序列。令人惊讶的是，这种“不专注”的反应也可以在药物停止后观察到，特别是当只有一个小奖励时。这些发现表明，NAcC D1 Rs的活动平衡在快速激活专注的奖励寻求状态，使动物能够有效和准确地实现目标方面起着关键作用。
It is well established that dopamine transmission is integral in mediating the influence of reward expectations on reward-seeking actions. However, the precise causal role of dopamine transmission in moment-to-moment reward-motivated behavioral control remains contentious, particularly in contexts where it is necessary to refrain from responding to achieve a beneficial outcome. To examine this, we manipulated dopamine transmission pharmacologically as rats performed a Go/No-Go task that required them to either make or withhold action to gain either a small or large reward. D1R Stimulation potentiated cue-driven action initiation, including fast impulsive actions on No-Go trials. By contrast, D1R blockade primarily disrupted the successful completion of Go trial sequences. Surprisingly, while after global D1R blockade this was characterized by a general retardation of reward-seeking actions, nucleus accumbens core (NAcC) D1R blockade had no effect on the speed of action initiation or impulsive actions. Instead, fine-grained analyses showed that this manipulation decreased the precision of animals’ goal-directed actions, even though they usually still followed the appropriate response sequence. Strikingly, such “unfocused” responding could also be observed off-drug, particularly when only a small reward was on offer. These findings suggest that the balance of activity at NAcC D1Rs plays a key role in enabling the rapid activation of a focused, reward-seeking state to enable animals to efficiently and accurately achieve their goal.
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影响因子：
19.9
作者：
Guitart-Masip, Marc;Duzel, Emrah;Dolan, Ray;Dayan, Peter
通讯作者：
Dayan, Peter
影响因子：
25
作者：
Eban-Rothschild A;Rothschild G;Giardino WJ;Jones JR;de Lecea L
通讯作者：
de Lecea L
影响因子：
3
作者：
du Hoffmann, Johann;Nicola, Saleem M.
通讯作者：
Nicola, Saleem M.
影响因子：
5.3
作者：
Baraduc, Pierre;Thobois, Stephane;Desmurget, Michel
通讯作者：
Desmurget, Michel
中断多巴胺对未来奖励编码的可取消成本和利益编码。
影响因子：
25
作者：
Gan JO;Walton ME;Phillips PE
通讯作者：
Phillips PE