Differential expression of nuclear hormone receptors by dendritic cell subsets in human vaginal mucosa and skin.
Differential expression of nuclear hormone receptors by dendritic cell subsets in human vaginal mucosa and skin.
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人类阴道粘膜和皮肤中的树突状细胞亚群对核激素受体的差异表达。
DOI：
10.3389/fimmu.2022.1063343
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
树突状细胞（DCs）表达的核激素受体（NHRs）是主要的免疫诱导和调节因子，在宿主免疫中发挥重要作用。评估阴道粘膜（VM）中DCs表达的NHRs，与其他组织中DCs表达的NHRs进行比较，将有助于我们了解人类阴道的免疫学。本研究确定了16个NHR转录本，这些转录本在从人VM、皮肤和血液中分离的8个不同的抗原呈递细胞（APC）亚群中差异表达。NHRs的表达谱在很大程度上具有组织特异性。VM APC表达水平增加的LXRA，RXRA，ESRRA，ESRRAP 2和PPARG，而皮肤和血液APC表达水平增加的ARM 1，NOR 1和RARA。有趣的是，发现雌性激素受体ESR 1和PGR主要由VM中的非APC细胞类型表达; ESR 1由HLA-DR+ CD 34+表达，PGR由HLA-DR-细胞表达。VM中vimentin+细胞表达ERα和PR，而人皮肤中不表达ERα和PR。VM固有层CD 10+细胞也表达ERα，而不表达PR。总之，APC亚群的NHR表达是组织和细胞类型特异性的。未来的研究中的作用，个人NHRs表达的不同类型的细胞，包括DC亚群，在人类VM是必要的。
Nuclear hormone receptors (NHRs) expressed by dendritic cells (DCs), the major immune inducers and regulators, could play important roles in host immunity. Assessment of NHRs expressed by DCs in the vaginal mucosa (VM), in comparison with those expressed by DCs in other tissues, will thus help us understand the immunology of human vagina. This study identified 16 NHR transcripts that are differentially expressed among 8 different antigen-presenting cell (APC) subsets isolated from human VM, skin, and blood. The expression profiles of NHRs were largely tissue specific. VM APCs expressed increased levels of LXRA, RXRA, ESRRA, ESRRAP2, and PPARG, whereas skin and blood APCs expressed increased levels of NURR1, NOR1 and RARA. Of interest, female sex hormone receptors, ESR1 and PGR, were found to be mainly expressed by non-APC cell types in the VM; ESR1 by HLA-DR+CD34+ and PGR by HLA-DR- cells. ERα and PR were expressed by vimentin+ cells in the VM, but not in human skin. ERα, but not PR, was also expressed in CD10+ cells in the lamina propria of VM. In conclusion, NHR expression by APC subsets is tissue- and cell type-specific. Future studies on the roles of individual NHRs expressed by different cell types, including DC subsets, in the human VM are warranted.
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DOI：
10.1034/j.1600-0897.2002.01141.x
发表时间：
2002-11-01
影响因子：
3.6
作者：
Canellada, A;Blois, S;Idehu, RAM
通讯作者：
Idehu, RAM
影响因子：
64.8
作者：
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影响因子：
4.4
作者：
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通讯作者：
Larregina, Adriana T.
影响因子：
12.3
作者：
Duluc, Dorothee;Banchereau, Romain;Oh, SangKon
通讯作者：
Oh, SangKon
影响因子：
4.5
作者：
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