A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI.
A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI.
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DOI：
10.1177/0271678x211037266
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Siero JCW
中科院分区：
文献类型：
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作者：
Raimondo L;Knapen T;Oliveira ĹAF;Yu X;Dumoulin SO;van der Zwaag W;Siero JCW
功能磁共振成像（fMRI）是神经科学中广泛使用的检测神经诱发反应的工具，例如血氧水平依赖（BOLD）信号。典型地，BOLD fMRI具有毫米空间分辨率和一到几秒的时间分辨率。为了研究大脑皮层灰质的亚毫米结构和活动，该领域需要一种具有高空间和时间分辨率的功能磁共振成像方法。线扫描功能磁共振成像实现了非常高的空间分辨率和高采样率，在牺牲体积覆盖的成本。在这里，我们提出了一个人的行扫描实现7 T MRI系统。首先，我们研究了抑制线外MR信号的饱和脉冲的质量。其次，我们确定了重建的最佳线圈组合。最后，我们在视觉刺激任务期间在枕叶应用线扫描方法，显示BOLD响应沿着皮层深度，每250 µm，重复时间（TR）为200 ms。我们发现t统计值与具有相同时间分辨率和体素体积的2D梯度回波平面回波成像（GE-EPI）BOLD fMRI数据具有良好的对应性（R = 0.6 ± 0.2）。总之，我们证明了线扫描在人类中的可行性，这打开了线扫描功能磁共振成像在认知和临床神经科学的应用。
Functional magnetic resonance imaging (fMRI) is a widely used tool in neuroscience to detect neurally evoked responses, e.g. the blood oxygenation level-dependent (BOLD) signal. Typically, BOLD fMRI has millimeter spatial resolution and temporal resolution of one to few seconds. To study the sub-millimeter structures and activity of the cortical gray matter, the field needs an fMRI method with high spatial and temporal resolution. Line-scanning fMRI achieves very high spatial resolution and high sampling rate, at the cost of a sacrifice in volume coverage. Here, we present a human line-scanning implementation on a 7T MRI system. First, we investigate the quality of the saturation pulses that suppress MR signal outside the line. Second, we established the best coil combination for reconstruction. Finally, we applied the line-scanning method in the occipital lobe during a visual stimulation task, showing BOLD responses along cortical depth, every 250 µm with a 200 ms repetition time (TR). We found a good correspondence of t-statistics values with 2D gradient-echo echo planar imaging (GE-EPI) BOLD fMRI data with the same temporal resolution and voxel volume (R = 0.6 ± 0.2). In summary, we demonstrate the feasibility of line-scanning in humans and this opens line-scanning fMRI for applications in cognitive and clinical neuroscience.
DOI：
10.1117/12.878305
发表时间：
2011-03-15
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
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作者：
Lee J;Ehlers C;Crews F;Niethammer M;Budin F;Paniagua B;Sulik K;Johns J;Styner M;Oguz I
通讯作者：
Oguz I