High frequency spinal cord stimulation-New method to restore cough.
High frequency spinal cord stimulation-New method to restore cough.
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DOI：
10.1016/j.resp.2016.07.001
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发表时间：
2016-10
影响因子：
2.3
通讯作者：
DiMarco, A. F.
中科院分区：
文献类型：
--
作者：
Kowalski, K. E.;Romaniuk, J. R.;Brose, S.;Richmond, M. A.;Kowalski, T.;DiMarco, A. F.
Spinal cord stimulation (SCS, 50Hz) is a useful method to restore an effective cough in persons with spinal cord injury (SCI). However, high stimulus amplitudes and potential activation of pain fibers, significantly limits this application. It is our hypothesis that high frequency SCS (HF-SCS), with low stimulus amplitudes may provide the same level of expiratory muscle activation. In 6 dogs, the effects of SCS, with varying stimulus parameters on positive pressure (P) generation was evaluated. At any given level of stimulus current, mean P was largest at 500Hz, compared to all other stimulus frequencies. For example, with stimulation at 1mA and frequencies of 200, 500 and 600Hz, P were 25±3, 58±4, 51±6cmH2O, respectively. By comparison, P achieved with conventional SCS parameters was 61±5cmH2O. HF-SCS results in a comparable P compared to that achieved with conventional stimulus parameters but with much lower stimulus amplitudes. This method may be useful to restore cough even in subjects with intact sensation.
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影响因子：
2.3
作者：
DiMarco, Anthony F.;Kowalski, Krzysztof E.
通讯作者：
Kowalski, Krzysztof E.
影响因子：
3.3
作者：
DiMarco, AF;Romaniuk, JR;Supinski, G
通讯作者：
Supinski, G
影响因子：
3.3
作者：
DiMarco, AF;Kowalski, KE;Romaniuk, JR
通讯作者：
Romaniuk, JR
DOI：
10.1164/rccm.200601-097cr
发表时间：
2006-06-15
影响因子：
24.7
作者：
DiMarco, AF;Kowalski, KE;Hromyak, DR
通讯作者：
Hromyak, DR
影响因子：
--
作者：
Corcia, Philippe;Pradat, Pierre-Francois;Meininger, Vincent
通讯作者：
Meininger, Vincent