Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer.
Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer.
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DOI：
10.7326/0003-4819-152-7-201004060-00009
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发表时间：
2010-04-06
影响因子：
39.2
通讯作者：
Oeffinger KC
中科院分区：
文献类型：
--
作者：
Henderson TO;Amsterdam A;Bhatia S;Hudson MM;Meadows AT;Neglia JP;Diller LR;Constine LS;Smith RA;Mahoney MC;Morris EA;Montgomery LL;Landier W;Smith SM;Robison LL;Oeffinger KC
接受胸部放射治疗的妇女可能会患乳腺癌。总结乳腺癌的风险和乳腺癌的监测妇女胸部放射治疗儿童或年轻的成年人癌症。来自MEDLINE、EMBASE、科克伦图书馆和CINAHL的研究（1966年至2008年12月）。选择回答以下3个问题的文章：1）儿童或年轻成人癌症胸部放疗后女性乳腺癌的发病率和额外风险是多少？2)对于这些女性，乳腺癌的临床特征和治疗后的结局是否与一般人群中的散发性乳腺癌女性不同？3)在暴露于胸部辐射的妇女中进行乳腺癌监测的潜在益处和危害是什么？三名研究者独立提取数据并评估研究质量。标准化发病率比值范围为13.3 - 55.5; 40-45岁乳腺癌累积发病率范围为13- 20%。乳腺癌的风险与胸部辐射剂量呈线性增加。现有的有限证据表明，这些妇女的乳腺癌特征和诊断后的结果与一般人群相似;这些乳腺癌可以通过乳房X线摄影检测出来，但灵敏度有限。局限性包括研究异质性、设计和样本量小。接受胸部放射治疗的妇女在年轻时患乳腺癌的风险大大增加，而且似乎没有达到平台期。在这些高危人群中，早期发现似乎有好处。需要进一步的研究来更好地定义终身监视的危害和好处。
Women treated with therapeutic chest radiation may develop breast cancer. Summarize breast cancer risk and breast cancer surveillance in women following chest radiation for a pediatric or young adult cancer. Studies from MEDLINE, EMBASE, Cochrane Library, and CINAHL (1966 through December 2008). Articles selected to answer any of 3 questions: 1) What is the incidence and excess risk of breast cancer in women following chest radiation for a pediatric or young adult cancer? 2) For these women, are the clinical characteristics of the breast cancer and the outcomes following therapy different than for women with sporadic breast cancer in the general population? 3) What are the potential benefits and harms associated with breast cancer surveillance among women exposed to chest radiation? Three investigators independently extracted data and assessed study quality. Standardized incidence ratios ranged from 13.3 to 55.5; cumulative incidence of breast cancer by 40–45 years of age ranged from 13–20%. Risk of breast cancer increased linearly with chest radiation dose. Available limited evidence suggests that the characteristics of the breast cancers in these women and the outcomes following diagnosis are similar to those in the general population; these breast cancers can be detected by mammography, though sensitivity is limited. Limitations include study heterogeneity, design and small sample size. Women treated with chest radiation have a substantially elevated risk of breast cancer at a young age, which does not appear to plateau. Among this high risk population, there appears to be a benefit associated with early detection. Further research is required to better define the harms and benefits of lifelong surveillance.
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影响因子：
3.5
作者：
Gervais-Fagnou, DD;Girouard, C;Goss, PE
通讯作者：
Goss, PE
影响因子：
1
作者：
Faulkner, K;Law, J
通讯作者：
Law, J
影响因子：
8.8
作者：
Griebsch, I.;Brown, J.;Boggis, C.;Dixon, A.;Dixon, M.;Easton, D.;Eeles, R.;Evans, D. G.;Gilbert, F. J.;Hawnaur, J.;Kessar, P.;Lakhani, S. R.;Moss, S. M.;Nerurkar, A.;Padhani, A. R.;Pointon, L. J.;Potterton, J.;Thompson, D.;Turnbull, L. W.;Walker, L. G.;Warren, R.;Leach, M. O.
通讯作者：
Leach, M. O.
影响因子：
3.3
作者：
Fay, Michael P
通讯作者：
Fay, Michael P
DOI：
10.1016/j.ijrobp.2008.04.067
发表时间：
2008-09-01
影响因子：
7
作者：
Constine, Louis S.;Tarbell, Nancy;Hudson, Melissa M.;Schwartz, Cindy;Fisher, Susan G.;Muhs, Ann G.;Basu, Swati K.;Kun, Larry E.;Ng, Andrea;Mauch, Peter;Sandhu, Ajay;Culakova, Eva;Lyman, Gary;Mendenhall, Nancy
通讯作者：
Mendenhall, Nancy