Circadian clock genes and risk of fatal prostate cancer.
Circadian clock genes and risk of fatal prostate cancer.
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DOI：
10.1007/s10552-014-0478-z
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发表时间：
2015-01
影响因子：
2.3
通讯作者：
Mucci, Lorelei A.
中科院分区：
文献类型：
--
作者：
Markt, Sarah C.;Valdimarsdottir, Unnur A.;Shui, Irene M.;Sigurdardottir, Lara G.;Rider, Jennifer R.;Tamimi, Rulla M.;Batista, Julie L.;Haneuse, Sebastien;Flynn-Evans, Erin;Lockley, Steven W.;Czeisler, Charles A.;Stampfer, Meir J.;Launer, Lenore;Harris, Tamara;Smith, Albert Vernon;Gudnason, Vilmundur;Lindstrom, Sara;Kraft, Peter;Mucci, Lorelei A.
昼夜节律基因可能参与调节癌症相关途径，包括细胞增殖、DNA损伤反应和凋亡。我们的目的是评估核心昼夜节律基因的遗传变异与致命性前列腺癌风险和晨尿6-硫酸氧褪黑激素水平的关系。我们使用非条件logistic回归评估AGES-Reykjavik队列（n=24例）、卫生专业人员随访研究（HPFS）（n=40例）和医生健康研究（PHS）（n=105例）中12个昼夜节律相关基因的96个单核苷酸多态性（SNP）与致命性前列腺癌的相关性。我们使用线性回归来评估SNPs与AGES-Reykjavik晨尿6-硫酸氧褪黑激素水平之间的相关性。我们使用内核机器测试来评估通路中的多标记SNP集（基于基因）是否与我们的结果相关。在三个队列中，没有一个SNP与致命的前列腺癌始终相关。在每个队列中，基于基因的分析显示，AGES-Reykjavik、HPFS和PHS的p-values分别为0.01、0.01和0.05。在AGES-Reykjavik中，TIMELESS（4个SNP），NPAS 2（6个SNP），PER 3（2个SNP）和CSNK 1 E（1个SNP）中的SNP与6-硫酸酯基褪黑激素水平名义上相关。我们没有发现核心生物钟基因的变异与致命性前列腺癌风险之间存在强而一致的相关性，但观察到致命性前列腺癌和6-硫酸氧褪黑激素水平之间存在名义上显著的基因相关性。
Circadian genes may be involved in regulating cancer-related pathways, including cell proliferation, DNA damage response and apoptosis. We aimed to assess the role of genetic variation in core circadian rhythm genes with the risk of fatal prostate cancer and morning void urinary 6-sulfatoxymelatonin levels. We used unconditional logistic regression to evaluate the association of 96 single-nucleotide polymorphisms (SNPs) across twelve circadian-related genes with fatal prostate cancer in the AGES-Reykjavik cohort (n=24 cases), the Health Professionals Follow-Up Study (HPFS) (n=40 cases), and the Physicians’ Health Study (PHS) (n=105 cases). We used linear regression to evaluate the association between SNPs and morning void urinary 6-sulfatoxymelatonin levels in AGES-Reykjavik. We used a kernel machine test to evaluate whether multimarker SNP-sets in the pathway (gene based) were associated with our outcomes. None of the individual SNPs were consistently associated with fatal prostate cancer across the three cohorts. In each cohort, gene-based analyses showed that variation in the CRY1 gene was nominally associated with fatal prostate cancer (p-values = 0.01, 0.01, 0.05 for AGES-Reykjavik, HPFS, and PHS, respectively). In AGES-Reykjavik, SNPS in TIMELESS (4 SNPs), NPAS2 (6 SNPs), PER3 (2 SNPs) and CSNK1E (1 SNP) were nominally associated with 6-sulfatoxymelatonin levels. We did not find a strong and consistent association between variation in core circadian clock genes and fatal prostate cancer risk, but observed nominally significant gene-based associations with fatal prostate cancer and 6-sulfatoxymelatonin levels.
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影响因子：
5.6
作者：
Evans, Daniel S.;Parimi, Neeta;Tranah, Gregory J.
通讯作者：
Tranah, Gregory J.
DOI：
10.1158/1055-9965.epi-11-0236
发表时间：
2011-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Lin DW;FitzGerald LM;Fu R;Kwon EM;Zheng SL;Kolb S;Wiklund F;Stattin P;Isaacs WB;Xu J;Ostrander EA;Feng Z;Grönberg H;Stanford JL
通讯作者：
Stanford JL
影响因子：
11.2
作者：
Gauger, MA;Sancar, A
通讯作者：
Sancar, A
影响因子：
3.5
作者：
Schumacher, Fredrick R.;Berndt, Sonja I.;Kraft, Peter
通讯作者：
Kraft, Peter
DOI：
10.1093/gerona/gls227
发表时间：
2013-06-01
影响因子：
5.1
作者：
Murphy, Rachel A.;Nalls, Michael A.;Harris, Tamara B.
通讯作者：
Harris, Tamara B.