Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children's Health Trajectories Birth Cohort Study.

Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children's Health Trajectories Birth Cohort Study.
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DOI:
10.1016/j.jpeds.2021.09.061
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发表时间:
2022-03
期刊:
The Journal of pediatrics
影响因子:
--
通讯作者:
Graham DR
Graham DR
中科院分区:
其他
文献类型:
--
作者:
Schleif WS;Harlan RS;Hamblin F;Amankwah EK;Goldenberg NA;Hernandez RG;Johnson SB;Reed S;Graham DR

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Newborn screening using Dried Plasma Spots (DPS) offers pre-analytical advantages over conventional cards for plasma-associated targets of interest. Herein we present DPS-based methods for measuring metabolites using a 400+ compound LC-MS/MS library. Quality assurance reduced this library to 134, and from these, 30 compounds determined the normal newborn reference ranges.
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