Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.
Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.
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DOI：
10.1016/j.neuron.2008.07.004
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发表时间：
2008-08-28
期刊：
影响因子：
16.2
通讯作者：
Nicola SM
中科院分区：
文献类型：
--
作者：
Ambroggi F;Ishikawa A;Fields HL;Nicola SM
Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established. Here, we test the hypothesis that the BLA drives NAc neuronal responses to reward-predictive cues. First, using a disconnection experiment, we show that the BLA and dopamine projections to the NAc interact to promote the reward-seeking behavioral response. Next, we demonstrate that BLA neuronal responses to cues precede those of NAc neurons, and that cue-evoked excitation of NAc neurons depends on BLA input. These results indicate that BLA input is required for dopamine to enhance the cue-evoked firing of NAc neurons, and that this enhanced firing promotes reward-seeking behavior.
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影响因子：
2.5
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Ghitza, UE;Fabbricatore, AT;West, MO
通讯作者：
West, MO
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3.3
作者：
Ishikawa, A.;Ambroggi, F.;Fields, H. L.
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Fields, H. L.
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