Sparse incomplete representations: a potential role of olfactory granule cells.

Sparse incomplete representations: a potential role of olfactory granule cells.
复制标题

DOI:
10.1016/j.neuron.2011.07.031
复制
发表时间:
2011-10-06
期刊:
影响因子:
16.2
通讯作者:
Rinberg D
Rinberg D
中科院分区:
医学1区
文献类型:
--
作者:
Koulakov AA;Rinberg D

文献摘要

参考文献

被引文献

相似文献

嗅球的二尖瓣/簇状细胞从受体神经元接收气味信息并将此信息传递到皮层。对清醒行为动物的研究发现,二尖瓣细胞对气味的持续反应是罕见的,这表明气味的稀疏组合表示。仔细对齐的二尖瓣细胞发射与呼吸周期的阶段显示短暂的短暂活动在较大的人口二尖瓣细胞,响应气味在一小部分的呼吸周期。因此,这些细胞的反应在时间上是稀疏的。在这里,我们提出了一个数学模型的嗅球网络,可以重现组合和时间稀疏的二尖瓣细胞代码。我们认为,稀疏编码的出现是由于二尖瓣细胞的兴奋性输入和颗粒细胞提供的抑制之间的平衡。我们的模型表明,介导二尖瓣和颗粒细胞之间的相互作用的树-树突触的功能意义。
Mitral/tufted cells of the olfactory bulb receive odorant information from receptor neurons and transmit this information to the cortex. Studies in awake behaving animals have found that sustained responses of mitral cells to odorants are rare, suggesting sparse combinatorial representation of the odorants. Careful alignment of mitral cell firing with the phase of the respiration cycle revealed brief transient activity in the larger population of mitral cells, which respond to odorants during a small fraction of the respiration cycle. Responses of these cells are therefore temporally sparse. Here, we propose a mathematical model for the olfactory bulb network that can reproduce both combinatorially and temporally sparse mitral cell codes. We argue that sparse codes emerge as a result of the balance between mitral cells' excitatory inputs and inhibition provided by the granule cells. Our model suggests functional significance for the dendrodendritic synapses mediating interactions between mitral and granule cells.
DOI: 10.1016/j.neuron.2010.01.009
发表时间: 2010-02-11
期刊: Neuron
影响因子: 16.2
作者:
Abraham NM;Egger V;Shimshek DR;Renden R;Fukunaga I;Sprengel R;Seeburg PH;Klugmann M;Margrie TW;Schaefer AT;Kuner T
通讯作者: Kuner T
DOI: 10.1038/376033a0
发表时间: 1995-07-06
期刊: NATURE
影响因子: 64.8
作者:
HOPFIELD, JJ
通讯作者: HOPFIELD, JJ
DOI: 10.1016/0013-4694(50)90075-7
发表时间: 1950-01-01
期刊: ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子: --
作者:
ADRIAN, ED
通讯作者: ADRIAN, ED
DOI: 10.1038/381607a0
发表时间: 1996-06-13
期刊: NATURE
影响因子: 64.8
作者:
Olshausen, BA;Field, DJ
通讯作者: Field, DJ
DOI: 10.1152/jn.00095.2008
发表时间: 2008-07-01
影响因子: 2.5
作者:
Fuentes, Romulo A.;Aguilar, Marcelo I.;Maldonado, Pedro E.
通讯作者: Maldonado, Pedro E.