Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer.
Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer.
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DOI：
10.1054/bjoc.2000.1508
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发表时间：
2000-12
影响因子：
8.8
通讯作者：
Monson J
中科院分区：
文献类型：
--
作者：
Chin KF;Greenman J;Gardiner E;Kumar H;Topping K;Monson J
我们的目的是确定术前血清血管内皮生长因子（VEGF）作为结直肠癌根治性切除术患者预后的预测因子的临床实用性。在81例淋巴结阴性（n = 53）和淋巴结阳性（n = 28）疾病的根治性切除术前，通过定量ELISA测定血清VEGF。无癌症死亡患者的中位随访时间为27个月（范围21-37）。术前血清VEGF在发生转移的患者中显著高于未发生转移的患者（中位数，713 pg ml-1 vs. 314 pg ml-1，P < 0.0001）。多因素考克斯回归分析显示，术前血清VEGF水平是最重要的预后因素，与淋巴结状态和辅助化疗无关，且在预测预后方面上级于淋巴结状态（P < 0.00001）。在575 pg ml-1时，术前血清VEGF在预测根治性切除术中转移瘤发展方面的敏感性为64%，特异性为89%，阳性预测值为73%，阴性预测值为85%。术前血清VEGF是结直肠癌根治性手术后预后的有力预测因子。这些数据支持测量术前血清VEGF作为选择需要辅助治疗的患者的方法。© 2000年癌症研究运动http://www.bjcancer.com
We aim to determine the clinical usefulness of pre-operative serum vascular endothelial growth factor (VEGF) as a predictor of outcome in patients undergoing curative resection for colorectal cancer. Serum VEGF was assayed by quantitative ELISA in 81 patients prior to curative resection for node-negative (n = 53) and node-positive (n = 28) disease. Median follow-up for patients without cancer death was 27 months (range 21–37). Pre-operative serum VEGF was significantly higher in patients who went on to develop metastases than those who did not (median, 713 pg ml–1 vs. 314 pg ml–1, P < 0.0001). Using multivariate Cox regression analysis, pre-operative serum VEGF was the most important prognostic factor independent of nodal status and adjuvant chemotherapy, and was superior to nodal status in predicting outcome (P < 0.00001). At 575 pg ml–1, pre-operative serum VEGF was 64% sensitive and 89% specific in predicting the development of metastases in curative resections, with a positive predictive value of 73% and a negative predictive value of 85%. Pre-operative serum VEGF is a powerful predictor of outcome following curative surgery for colorectal cancer. These data support the measurement of pre-operative serum VEGF as a method for selecting patients who require adjuvant therapy. © 2000 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
9.6
作者：
WILLIAMS, NS;JASS, JR;HARDCASTLE, JD
通讯作者：
HARDCASTLE, JD
影响因子：
45.3
作者：
Erlichman, C;O'Connell, M;Francini, G
通讯作者：
Francini, G
影响因子：
8.8
作者：
Ishigami, SI;Arii, S;Furutani, M;Niwano, M;Harada, T;Mizumoto, M;Mori, A;Onodera, H;Imamura, M
通讯作者：
Imamura, M
影响因子：
45.3
作者：
Riethmüller, G;Holz, E;Pichlmayr, R
通讯作者：
Pichlmayr, R
影响因子：
1.9
作者：
MILLER, R;SIEGMUND, D
通讯作者：
SIEGMUND, D