High-resolution diffusion tensor imaging of the human kidneys using a free-breathing, multi-slice, targeted field of view approach.
High-resolution diffusion tensor imaging of the human kidneys using a free-breathing, multi-slice, targeted field of view approach.
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DOI：
10.1002/nbm.3190
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发表时间：
2014-11
影响因子：
2.9
通讯作者：
Atkinson, David
中科院分区：
文献类型：
--
作者：
Chan, Rachel W.;Von Deuster, Constantin;Stoeck, Christian T.;Harmer, Jack;Punwani, Shonit;Ramachandran, Navin;Kozerke, Sebastian;Atkinson, David
通过扩散张量成像（DTI）获得的各向异性分数（FA）可用于在没有任何造影剂的情况下对肾脏进行成像。髓质的FA已被证明与肾功能相关。预计更高的空间分辨率将改善肾脏内小结构的描绘。然而，由于呼吸运动和对弥散成像伪影的敏感性，在肾脏DTI中实现高空间分辨率仍然具有挑战性。在这项研究中，一个有针对性的视野（TFOV）的方法被用来获得高分辨率FA地图和彩色编码的扩散张量的方向，连同测量的髓质和皮质FA，在12名健康受试者。受试者扫描两个实现（双肾和单肾）的TFOV DTI方法。在自由呼吸期间使用导航器触发序列进行DTI扫描。结果显示，受试者之间以及双肾和单肾扫描之间的灰度FA、彩色编码FA和扩散张量具有高度一致性，其平面内体素尺寸分别为2 × 2 mm2和1.2 × 1.2 mm2。采集多个连续切片的能力允许在整个肾脏体积上量化髓质和皮质FA。双肾扫描的平均髓质和皮质FA值分别为0.38 ± 0.017和0.21 ± 0.019，单肾扫描的平均髓质和皮质FA值分别为0.35 ± 0.032和0.20 ± 0.014。对于双肾和单肾实施，髓质和皮质之间的平均FA显著不同（p < 0.001）。高空间分辨率的DTI显示改善肾功能的表征和非侵入性评估的前景。© 2014作者。NMR in Biomedicine，John Wiley & Sons，Ltd.
Fractional anisotropy (FA) obtained by diffusion tensor imaging (DTI) can be used to image the kidneys without any contrast media. FA of the medulla has been shown to correlate with kidney function. It is expected that higher spatial resolution would improve the depiction of small structures within the kidney. However, the achievement of high spatial resolution in renal DTI remains challenging as a result of respiratory motion and susceptibility to diffusion imaging artefacts. In this study, a targeted field of view (TFOV) method was used to obtain high-resolution FA maps and colour-coded diffusion tensor orientations, together with measures of the medullary and cortical FA, in 12 healthy subjects. Subjects were scanned with two implementations (dual and single kidney) of a TFOV DTI method. DTI scans were performed during free breathing with a navigator-triggered sequence. Results showed high consistency in the greyscale FA, colour-coded FA and diffusion tensors across subjects and between dual- and single-kidney scans, which have in-plane voxel sizes of 2 × 2 mm2 and 1.2 × 1.2 mm2, respectively. The ability to acquire multiple contiguous slices allowed the medulla and cortical FA to be quantified over the entire kidney volume. The mean medulla and cortical FA values were 0.38 ± 0.017 and 0.21 ± 0.019, respectively, for the dual-kidney scan, and 0.35 ± 0.032 and 0.20 ± 0.014, respectively, for the single-kidney scan. The mean FA between the medulla and cortex was significantly different (p < 0.001) for both dual- and single-kidney implementations. High-spatial-resolution DTI shows promise for improving the characterization and non-invasive assessment of kidney function. © 2014 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd.
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